ArticleInternational journal of occupational medicine and environmental health2022
An assessment of unstimulated salivary flow rate, IgA and clinical oral dryness among active and passive smokers.
Article in International journal of occupational medicine and environmental health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 11 citations in OpenAlex.
- A systems biology network analysis of root resorption biomarkers and their clinical relevance in orthodontics: a pilot study.Genomics & informatics · 2026Article
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- Clinical Investigation of Periodontal Health in Smoker and Nonsmoker Individuals.International journal of dentistry · 2026Article
- Association Between Tobacco and Periodontal Disease in Latin America from 2000 to 2024: Cross-Sectional Analysis of Global Burden of Disease Study.Journal of clinical medicine · 2025Article
- Oral Health-Related Quality of Life and Oral Health Indices in Patients With Opioid Use Disorder Undergoing Methadone Maintenance Treatment.International journal of dentistry · 2025Article
- The Impact of Electronic and Conventional Cigarette Use towards Saliva Profile and Oral Microbiota in Adolescents.Asian Pacific journal of cancer prevention : APJCP · 2025Observational
- Salivary Profile Analysis Based on Oral Cancer Risk Habits: An Observational Cross-Sectional Study.Biomedicines · 2024Article
- Clinical characteristics and caries risk assessment of tobacco heating systems smokers, cigarette smokers and non-smokers: a cross-sectional study.Clinical oral investigations · 2024Article
- The prevalence of xerostomia among e-cigarette or combustible tobacco users: A systematic review and meta-analysis.Tobacco induced diseases · 2023Article
- Article
- Impact ofJournal of oral biology and craniofacial researchArticle
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to assess the impact of smoking on the whole salivary flow rate (SFR), IgA levels and clinical oral dryness (COD) among active and passive smokers. MATERIAL AND
methodsThe participants were categorized as active smokers (N = 54) or passive smokers (N = 163). Saliva was collected in tubes and placed in ice storage at -70°C. Salivary IgA levels were assessed in duplication using the enzyme linked immunosorbent assay (ELISA) method. Following the saliva sample collection, the subjects were assessed for COD using the COD score, SFR and caries. Chi-square test, the t-test and ANOVA were employed to compare the clinical impact of the smoking status associated with specific variables (smoking status, number of cigarettes, active caries, gender, age, COD score, IgA level and SFR). A p-value of <0.05 was considered significant.
resultsTwo hundred and seventeen subjects with the mean age of 32.86±6.30 years, with 145 males (66.8%) and 72 females (33.2%), were included in the study. Among the active smokers, 88.8% were males compared to 11.2% females. The active smokers had the mean age of 32.52 years, a COD score of 1.43, an IgA level of 1.39 g/l, and a SFR of 0.37 ml/min. Among the passive smokers, 59.5% were males and 40.5% were females, with the mean age of 32.97 years, a COD score of 0.87 g/l, an IgA level of 1.47, and a SFR of 0.42 ml/min. Active caries showed a positive correlation with the number of cigarettes, with significance in the >35 years age group (p < 0.05).
conclusionsThe study demonstrated significant differences in SFR, IgA and COD scores among the active and passive smokers. The number of cigarettes had a negative impact on saliva production, IgA levels, the oral health status, and the progression of caries with respect to age and gender. Smoking potentially leads to xerostomia associated with active caries. Int J Occup Med Environ Health. 2022;35(1):39-51.
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