Evidence map›Paper›PMID 34569453›Full record

ReviewPathogens and global health2022

Evolving strategies for meningococcal vaccination in Europe: Overview and key determinants for current and future considerations.

Federico Martinón-Torres, Muhamed-Kheir Taha, Markus Knuf, Victoria Abbing-Karahagopian, Michele Pellegrini, Rafik Bekkat-Berkani, Véronique Abitbol

Open access · greenAbstract readReview
In one paragraph

Review in Pathogens and global health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. An unusual presentation of meningococcal meningitis.American journal of ophthalmology case reports · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
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  11. Article
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  14. Review
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  16. Article
  17. Meningococcal meningitis in Spain in the Horizon 2030: A position paper.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024
    Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Federico Martinón-TorresGenetics, Vaccines and Pediatric Infectious Diseases Research Group (GENVIP, Instituto De Investigación Sanitaria De Santiago and Universidad De Santiago De Compostela (Usc), Santiago de Compostela, Galicia, Spain.ORCID 0000-0002-9023-581X
Muhamed-Kheir TahaInstitut Pasteur, Invasive Bacterial Infections Unit, National Reference Centre for Meningococci and Haemophilus Influenza, Paris, France.ORCID 0000-0002-0716-3174
Markus KnufKlinik Für Kinder- Und Jugendmedizin, Worms, Germany and Pediatric Infectious Diseases, University Medicine, Mainz, Germany.
Victoria Abbing-KarahagopianGSK, Amsterdam, The Netherlands.ORCID 0000-0003-1987-363X
Michele PellegriniGSK, Siena, Italy.ORCID 0000-0001-8505-9260
Rafik Bekkat-BerkaniGSK, Rockville, MD, United States.ORCID 0000-0003-0683-6055
Véronique AbitbolGSK, Rueil-Malmaison, France.ORCID 0000-0003-0369-7715
GGD Amsterdam · NLGlaxoSmithKline (United States) · USInstituto de Investigación Sanitaria de Santiago · ESInstitut Pasteur · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invasive meningococcal disease (IMD) is a life-threatening, unpredictable condition. Vaccines are available against 5 of the 6 meningococcal serogroups (Men) accounting for nearly all IMD cases worldwide; conjugate monovalent MenC, quadrivalent MenACWY, and protein-based MenB vaccines are commonly used. We provide a comprehensive overview of the evolution of meningococcal vaccination strategies employed in national immunization programmes (NIPs) and their impact on IMD incidence in Europe. A more in-depth description is given for several countries: the United Kingdom (UK), the Netherlands, Greece, Italy, and Ireland. We searched European health authorities' websites and PubMed. Various vaccines and immunization schedules are used in 21 NIPs. Most countries implement MenC vaccination in infants, MenACWY in adolescents, and a growing number, MenB in infants. Only Malta has introduced MenACWY vaccination in infants, and several countries reimburse immunization of toddlers. The UK, Italy, Ireland, Malta, Andorra, and San Marino recommend MenB vaccination in infants and MenACWY vaccination in adolescents, targeting the most prevalent serogroups in the most impacted age groups. Main factors determining new vaccination strategies are fluctuating IMD epidemiology, ease of vaccine implementation, ability to induce herd protection, favorable benefit-risk balance, and acceptable cost-effectiveness. Since 1999, when the UK introduced MenC vaccination, the reduction in IMD incidence has been gradually enhanced as other countries adopted routine meningococcal vaccinations. Meningococcal vaccination strategies in each country are continually adapted to regional epidemiology and national healthcare priorities. Future strategies may include broader coverage vaccines when available (e.g., MenABCWY, MenACWY), depending on prevailing epidemiology.

Indexed as

Meningococcal InfectionsMeningococcal VaccinesNeisseria meningitidisAdolescentEuropeFemaleHumansImmunization ProgramsInfantMaleVaccinationVaccines, ConjugateMeningococcal VaccinesVaccines, ConjugateEuropeInvasive meningococcal diseaseMenACWY vaccinationMenB vaccinationmeningococcal vaccinationnational immunization programmestrategies

Identifiers

PMID34569453
PMCPMC8933022
OpenAlexW3203563073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.