Evidence map›Paper›PMID 34569352›Full record

ArticleInternational journal of immunopathology and pharmacology

Complete blood cell count-derived ratios can be useful biomarkers for neurological diseases.

Fabiana Novellino, Annalidia Donato, Natalia Malara, Jose Lm Madrigal, Giuseppe Donato

Open access · goldAbstract readLetter
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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  10. Modeling the ratio of correlated biomarkers using copula regression.Statistical methods in medical research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Fabiana NovellinoNeuroimaging Research Unit, Institute of Molecular Bioimaging and Physiology, National Research Council, Catanzaro, Italy.ORCID https://orcid.org/0000-0002-5898-938X
Annalidia DonatoDepartment of Medical and Surgical Sciences, University of Catanzaro "Magna Graecia," Catanzaro, Italy.
Natalia MalaraDepartment of Clinical and Experimental Medicine, University of Catanzaro "Magna Graecia," Catanzaro, Italy.
Jose Lm MadrigalDepartment of Pharmacology and Toxicology, School of Medicine, Universidad Complutense de Madrid (UCM), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Investigación Neuroquímica (IUINQ-UCM), Instituto de Investigación Sanitaria Hospital 12 de Octubre (Imas12)Madrid, Spain.ORCID https://orcid.org/0000-0002-1409-9561
Giuseppe DonatoDepartment of Health Sciences, University of Catanzaro "Magna Graecia," Catanzaro, Italy.
Magna Graecia University · ITUniversidad Complutense de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complete blood cell count-derived parameters such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) have recently shown to be highly sensitive biomarkers. Their usefulness has been proven as prognostic factors in several cancers, in the stratification of mortality in major cardiac events, as predictors and markers of infectious or inflammatory pathologies, and in many other conditions. Surprisingly, the study of these biomarkers in neurological diseases is somewhat limited. This paper aims to take stock of the data present in the literature regarding the complete blood cell count-derived ratios in this group of pathologies and to formulate a hypothesis, based on the most recent data concerning innate and acquired immunity, on which diseases of the nervous system could benefit in diagnostic and prognostic terms from the in-depth study of these new biomarkers.

Indexed as

BiomarkersBlood Cell CountBlood PlateletsHumansLeukocyte CountLymphocyte CountLymphocytesMonocytesNervous System DiseasesNeutrophilsPlatelet CountPrognosisBiomarkersBlood cell count-derived ratioslymphocyte-to-monocyte rationeurologyneutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratiopsychiatrics

Identifiers

PMID34569352
PMCPMC8477675
OpenAlexW3202449969

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.