ArticleCancer control : journal of the Moffitt Cancer Center
Effect of Helicobacter Pylori on Plasma Metabolic Phenotype in Patients With Gastric Cancer.
Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 8 citations in OpenAlex.
- Mendelian Randomization Analysis of Human Blood Metabolites and Sensorineural Hearing Loss.Brain and behavior · 2026Article
- ssNetShift: single-sample metabolic network rewiring reveals hidden prognostic subtypes beyond clinical staging in gastric cancer.Briefings in bioinformatics · 2026Article
- Therapeutic Effects of Sulforaphane onInternational journal of molecular sciences · 2025Article
- Plasma metabolome identifies potential biomarkers of gastric precancerous lesions and gastric cancer risk.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Neurogenesis manifestations of solid tumor and tracer imaging studies: a narrative review.American journal of cancer research · 2023Review
- Different Metabolites of the Gastric Mucosa between Patients with CurrentBiomedicines · 2022Article
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundAlthough PURPOSE: Herein, plasma of human superficial gastritis (Hp negative and positive), early gastric cancer and advanced gastric cancer analyzed by UPLC-HDMS metabolomics can not only reveal metabolic phenotype changes in patients with gastric cancer of different degrees (30 Hp negative, 30 Hp positive, 20 early gastric cancer patients, and 10 advanced gastric cancer patients), but also auxiliarily diagnose gastric cancer.
resultsCombined with multivariate statistical analysis, the results represented biomarkers different from Hp negative, Hp positive, and the alterations of metabolic phenotype of gastric cancer patients. Forty-three metabolites are involved in amino acid metabolism, and lipid and fatty acid metabolism pathways in the process of cancer occurrence, especially 2 biomarkers glycerophosphocholine and neopterin, were screened in this study. Neopterin was consistently increased with gastric cancer progression and glycerophosphocholine tended to consistently decrease from Hp negative to advanced gastric cancer.
conclusionThis method could be used for the development of rapid targeted methods for biomarker identification and a potential diagnosis of gastric cancer.
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