Evidence map›Paper›PMID 34569287›Full record

ReviewAntioxidants & redox signaling2021

Salt Sensitivity of Blood Pressure in Blacks and Women: A Role of Inflammation, Oxidative Stress, and Epithelial Na

Melis Sahinoz, Fernando Elijovich, Lale A Ertuglu, Jeanne Ishimwe, Ashley Pitzer, Mohammad Saleem, Naome Mwesigwa, Thomas R Kleyman, Cheryl L Laffer, Annet Kirabo

Open access · greenAbstract readReview
In one paragraph

Review in Antioxidants & redox signaling, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Animal models of hypertension and concurrent organs injury.Animal models and experimental medicine · 2025
    Review
  6. Review
  7. Review
  8. Epithelial Na+ Channels, Immune Cells, and Salt.Annual review of physiology · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Revisiting sex as a biological variable in hypertension research.The Journal of clinical investigation · 2024
    Review
  13. Complete autonomic blockade reveals nitric oxide contribution to blood pressure regulation in obese Black women.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Article
  14. Article
  15. Epithelial NaComprehensive Physiology · 2024
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Melis SahinozDivision of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Fernando ElijovichDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Lale A ErtugluDivision of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jeanne IshimweDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Ashley PitzerDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Mohammad SaleemDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Naome MwesigwaDepartment of Medicine and Dentistry, Kampala International University, Kampala, Uganda.
Thomas R KleymanDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Cheryl L LafferDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Annet KiraboDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-8580-9359
Vanderbilt University Medical Center · USKampala International University · UGUniversity of Pittsburgh · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
ENaC regulation and its role in blood pressure homeostasisR01HL147818 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Annet Kirabo, Thomas R Kleyman · 2019 to 2026
$4.6M
Immune Mechanisms of Salt-Sensitive hypertensionR01HL144941 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIRABO, ANNET · 2021 to 2025
$3.0M
Role of Salt, Isoketal-modified Proteins and Dendritic Cells in HypertensionK01HL130497 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIRABO, ANNET · 2016 to 2020
$803k
Deep phenotypic and functional characterization of salt-responsive immune cells in human salt senstive hypertension using CTE-seqR03HL155041 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIRABO, ANNET · 2021 to 2022
$173k
NHLBI NIH HHS K01 HL130497NHLBI NIH HHS R01 HL144941NHLBI NIH HHS R01 HL147818NHLBI NIH HHS R03 HL155041NIDDK NIH HHS P30 DK079307
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HypertensionSodium Chloride, DietaryBlack or African AmericanBlood PressureFemaleHumansInflammationOxidative StressSodiumSodiumSodium Chloride, Dietaryoxidative stressracial differencessalt sensitivity of blood pressuresex differences

Identifiers

PMID34569287
PMCPMC8713266
OpenAlexW3204034928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.