Evidence map›Paper›PMID 34569183›Full record

ArticlePhysiological reports2021

PDE9A deficiency does not prevent chronic-hypoxic pulmonary hypertension in mice.

Todd M Kolb, Laura Johnston, Mahendra Damarla, David A Kass, Paul M Hassoun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Cardiac cGMP Regulation and Therapeutic Applications.Hypertension (Dallas, Tex. : 1979) · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Todd M KolbDivision of Pulmonary and Critical Care Medicine Pulmonary, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0003-0524-7400
Laura JohnstonDivision of Pulmonary and Critical Care Medicine Pulmonary, Johns Hopkins University, Baltimore, Maryland, USA.
Mahendra DamarlaDivision of Pulmonary and Critical Care Medicine Pulmonary, Johns Hopkins University, Baltimore, Maryland, USA.
David A KassDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Paul M HassounDivision of Pulmonary and Critical Care Medicine Pulmonary, Johns Hopkins University, Baltimore, Maryland, USA.
Johns Hopkins University · US

Funding

Leveraging Protein Kinase G-1 Nanodomain Control and Molecular Targeting to Enhance its Therapeutic Use Against Myocardial DiseaseR35HL135827 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KASS, DAVID ALAN · 2017 to 2023
$6.3M
NHLBI NIH HHS R35 HL135827
6 · The paper itself

Abstract

Inhibition of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterases (PDEs) is a cornerstone of pulmonary arterial hypertension (PAH)-specific therapy. PDE9A, expressed in the heart and lung tissue, has the highest affinity for cGMP of all known PDEs. PDE9A deficiency protects mice against chronic left ventricular (LV) pressure overload via increased natriuretic peptide (NP)-dependent cGMP signaling. Chronic-hypoxic pulmonary hypertension (CH-PH) is a model of chronic right ventricular (RV) pressure overload, and previous studies have demonstrated a protective role for NPs in the murine model. Therefore, we hypothesized that PDE9A deficiency would promote NP-dependent cGMP signaling and prevent RV remodeling in the CH-PH model, analogous to findings in the LV. We exposed wild-type and PDE9A-deficient (Pde9a

Indexed as

3',5'-Cyclic-AMP PhosphodiesterasesAnimalsAtrial Natriuretic FactorBlood PressureCell Adhesion MoleculesCyclic GMPHeart VentriclesHypertension, PulmonaryHypoxiaLungMiceMice, Inbred C57BLMicrofilament ProteinsPhosphoproteinsSignal TransductionVasodilator-Stimulated Phosphoprotein3',5'-Cyclic-AMP PhosphodiesterasesAtrial Natriuretic FactorCell Adhesion MoleculesCyclic GMPMicrofilament ProteinsPde9a protein, mousePhosphoproteinsVasodilator-Stimulated Phosphoproteinchronic hypoxiamouse modelphosphodiesterase 9Apulmonary hypertension

Identifiers

PMID34569183
PMCPMC8474007
OpenAlexW3203509213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.