Evidence map›Paper›PMID 34569176›Full record

ArticleInternational forum of allergy & rhinology2022

Sox2 regulates globose basal cell regeneration in the olfactory epithelium.

Zhexuan Li, Ming Wei, Wenjuan Shen, Heather Kulaga, Mengfei Chen, Andrew P Lane

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International forum of allergy & rhinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Therapeutic Effects ofLife (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Zhexuan LiDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ming WeiDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Wenjuan ShenDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Heather KulagaDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Mengfei ChenDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Andrew P LaneDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins University · USJohns Hopkins Medicine · USCentral South University · CN

Funding

Innate Immune Regulation of the Epithelium in Chronic Rhinosinusitis with Nasal PolypsR01AI132590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI LANE, ANDREW P · 2018 to 2022
$3.0M
Inflammation-Associated Olfactory Dysfunction: Mechanisms and TherapyR01DC016106 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI LANE, ANDREW P · 2018 to 2022
$2.7M
NIAID NIH HHS R01 AI132590NIDCD NIH HHS R01 DC016106
6 · The paper itself

Abstract

backgroundIn the olfactory epithelium, mitotically active globose basal cells (GBCs) continuously replenish olfactory sensory neurons (OSNs) lost throughout life. Although an essential role of the transcription factor Sox2 in expanding olfactory progenitors/stem cells has been shown, its precise role in olfactory GBCs remain incompletely understood.

methodsWe characterized the Sox2 expression in olfactory GBCs in normal conditions and in a lesion-regeneration model using a Lgr5EGFP-IRES-creERT2 strain. During GBC-mediated regeneration, genetic deletion of sox2 and lineage tracing experiments were performed to examine the function of Sox2 in the progeny of Lgr5-EGFP

resultsOver 95% of Lgr5-EGFP

conclusionsOur observations support an essential role of Sox2 in adult olfactory regeneration, likely acting on neuronal-lineage GBCs.

Indexed as

Olfactory MucosaOlfactory Receptor NeuronsCell DifferentiationHumansRegenerationSOXB1 Transcription FactorsStem CellsSOX2 protein, humanSOXB1 Transcription FactorsdifferentiationGlobose basal cellsolfactory epitheliumregenerationSox2

Identifiers

PMID34569176
PMCPMC8860864
OpenAlexW3203331381

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.