Evidence map›Paper›PMID 34569136›Full record

ArticleChembiochem : a European journal of chemical biology2021

Structural Studies Provide New Insights into the Role of Lysine Acetylation on Substrate Recognition by CARM1 and Inform the Design of Potent Peptidomimetic Inhibitors.

Yurui Zhang, Nils Marechal, Matthijs J van Haren, Nathalie Troffer-Charlier, Vincent Cura, Jean Cavarelli, Nathaniel I Martin

Open access · hybridAbstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. PRMT3 and CARM1: Emerging Epigenetic Targets in Cancer.Journal of cellular and molecular medicine · 2025
    Review
  3. The emerging role of CARM1 in cancer.Cellular oncology (Dordrecht, Netherlands) · 2024
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yurui ZhangBiological Chemistry Group, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE, Leiden (The, Netherlands.
Nils MarechalDepartment of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, CNRS UMR 7104, INSERM U 1258, Illkirch, 67404, France.ORCID 0000-0002-4239-9625
Matthijs J van HarenBiological Chemistry Group, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE, Leiden (The, Netherlands.ORCID 0000-0003-0251-071X
Nathalie Troffer-CharlierDepartment of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, CNRS UMR 7104, INSERM U 1258, Illkirch, 67404, France.ORCID 0000-0001-6812-8375
Vincent CuraDepartment of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, CNRS UMR 7104, INSERM U 1258, Illkirch, 67404, France.ORCID 0000-0003-2586-510X
Jean CavarelliDepartment of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, CNRS UMR 7104, INSERM U 1258, Illkirch, 67404, France.ORCID 0000-0001-8620-8723
Nathaniel I MartinBiological Chemistry Group, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE, Leiden (The, Netherlands.ORCID 0000-0001-8246-3006
Centre National de la Recherche Scientifique · FRLeiden University · NL

Funding

Agence Nationale de la Recherche ANR-19-CE11-0010-01Association pour la Recherche contre le Cancer PJA 20161204817Chinese Scholarship Council 201706210082CNRSEuropean Strategy Forum on Research InfrastructuresFrench Infrastructure for Integrated Structural Biology ANR-10-INSB-005French Infrastructure for Integrated Structural Biology ANR-10-LABX-0030-INRTINSERMInstruct-ERICLigue d'Alsace contre le CancerUniversité de Strasbourg
6 · The paper itself

Abstract

The dynamic interplay of post-translational modifications (PTMs) in chromatin provides a communication system for the regulation of gene expression. An increasing number of studies have highlighted the role that such crosstalk between PTMs plays in chromatin recognition. In this study, (bio)chemical and structural approaches were applied to specifically probe the impact of acetylation of Lys

Indexed as

Drug DesignAcetylationAnimalsCrystallography, X-RayEnzyme InhibitorsLysineMiceModels, MolecularPeptidomimeticsProtein-Arginine N-MethyltransferasesProtein ConformationSubstrate Specificitycoactivator-associated arginine methyltransferase 1Enzyme InhibitorsLysinePeptidomimeticsProtein-Arginine N-Methyltransferasesarginine methylationCARM1crosstalkcrystallographyinhibitorspeptidomimetics

Identifiers

PMID34569136
PMCPMC9293414
OpenAlexW3201861685

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.