Evidence map›Paper›PMID 34569014›Full record

ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2021

Frequency and outcomes of gastrointestinal symptoms in patients with Corona Virus Disease-19.

Hayley K Rogers, WonSeok W Choi, Niraj Gowda, Saadia Nawal, Brittney Gordon, Chinelo Onyilofor, Callie M Rogers, David Yamane, Marie L Borum

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In one paragraph

Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Diarrhea and Coronavirus Disease 2019 Infection.Gastroenterology clinics of North America · 2023
    Review
  3. Editorial commentary on Indian Journal of Gastroenterology-September-October 2021.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hayley K RogersDepartment of Internal Medicine, George Washington University, 2150 Pennsylvania Avenue, NW Suite 5-416, Washington, D.C., 20037, USA. hkrogers@gwu.edu.ORCID 0000-0001-7243-8034
WonSeok W ChoiDepartment of Internal Medicine, George Washington University, 2150 Pennsylvania Avenue, NW Suite 5-416, Washington, D.C., 20037, USA.
Niraj GowdaDepartment of Internal Medicine, George Washington University, 2150 Pennsylvania Avenue, NW Suite 5-416, Washington, D.C., 20037, USA.
Saadia NawalDepartment of Internal Medicine, George Washington University, 2150 Pennsylvania Avenue, NW Suite 5-416, Washington, D.C., 20037, USA.
Brittney GordonSchool of Medicine and Health Sciences, George Washington University, Ross Hall, 2300 Eye Street, NW, Washington, D.C., 20037, USA.
Chinelo OnyiloforSchool of Medicine and Health Sciences, George Washington University, Ross Hall, 2300 Eye Street, NW, Washington, D.C., 20037, USA.
Callie M RogersCollege of Veterinary Medicine and Biomedical Sciences, Texas A and M University, Veterinary and Biomedical Education Complex, 660 Raymond Stotzer Pkwy, College Station, 77843, TX, USA.
David YamaneDepartment of Emergency Medicine, Department of Anesthesia and Critical Care, George Washington University, 900 23rd St NW, Washington, D.C., 20037, USA.
Marie L BorumDivision of Gastroenterology and Liver Diseases, George Washington University, 22nd and I Street, NW, 3rd Floor, Washington, D.C., 20037, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo characterize the frequency and association of gastrointestinal (GI) symptoms with outcomes in patients with corona virus disease 2019  (COVID-19) admitted to the hospital.

methodsRecords were retrospectively collected from patients admitted to a tertiary care center in Washington, D.C., with confirmed COVID-19 from March 15, 2020  to July 15, 2020. After adjusting for clinical demographics and comorbidities, multivariate logistic regression analysis was performed.

resultsThe most common  presenting symptoms of COVID-19 in patients that were admitted to the hospital were cough (38.4%), shortness of breath (37.5%), and fever (34.3%), followed by GI symptoms in 25.9% of patients. The most common GI symptom was diarrhea (12.8%) followed by nausea or vomiting (10.5%), decreased appetite (9.3%), and abdominal pain (3.8%). Patients with diarrhea were more likely to die (odds ratio [OR] 2.750; p = 0.006; confidence interval [CI] 1.329-5.688), be admitted to the intensive care unit (ICU) (OR 2.242; p = 0.019; CI 1.139-4.413), and be intubated (OR 3.155; p = 0.002; CI 1.535-6.487). Additional outcomes analyzed were need for vasopressors, presence of shock, and acute kidney injury. Patients with  diarrhea  were 2.738 (p = 0.007; CI 1.325-5.658), 2.467 (p = 0.013; CI 1.209-5.035), and 2.694 (p = 0.007; CI 1.305-5.561) times more likely to experience these outcomes, respectively.

conclusionsScreening questions should be expanded to include common GI symptoms in patients with COVID-19. Health care providers should note whether their patient is presenting with diarrhea due to the potential implications on disease severity and outcomes.

Indexed as

COVID-19Gastrointestinal DiseasesDiarrheaHumansRetrospective StudiesSARS-CoV-2BetacoronavirusCOVID-19DiarrheaHospitalized patientsNovel conrona virusPandemicSARS-CoV-2

Identifiers

PMID34569014
PMCPMC8475883

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.