Evidence map›Paper›PMID 34568976›Full record

ArticleCellular and molecular life sciences : CMLS2021

Regulatory role and mechanisms of myeloid TLR4 in anti-GBM glomerulonephritis.

Fuye Yang, Jiaoyi Chen, Xiao Ru Huang, Wai Han Yiu, Xueqing Yu, Sydney C W Tang, Hui Yao Lan

Open access · hybridAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. T-Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  12. Single-cell RNA Sequencing Identified Novel Nr4a1Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Fuye YangDepartment of Nephrology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, People's Republic of China.
Jiaoyi ChenDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, People's Republic of China.
Xiao Ru HuangDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, People's Republic of China.
Wai Han YiuDivision of Nephrology, Department of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Xueqing YuGuangdong-Hong Kong Joint Laboratory on Immunological and Genetic Kidney Diseases, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, 510080, People's Republic of China.
Sydney C W TangDivision of Nephrology, Department of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Hui Yao LanDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, People's Republic of China. hylan@cuhk.edu.hk.ORCID http://orcid.org/0000-0003-4283-9755
Chinese University of Hong Kong · HKGuangdong Academy of Medical Sciences · CN

Funding

Research Grants Council of Hong Kong 14104019Research Grants Council of Hong Kong 14117418Research Grants Council of Hong Kong 14121816Research Grants Council of Hong Kong 14163317Research Grants Council of Hong Kong C7018-16GResearch Grants Council of Hong Kong R4012-18The Guangdong-Hong Kong-Macao-Joint Labs Program from Guangdong Science and Technology Department 2019B121205005the Lui Che Woo Institute of Innovative Medicine CARE program
6 · The paper itself

Abstract

Myeloid cells and TLR4 play a critical role in acute kidney injury. This study investigated the regulatory role and mechanisms of myeloid TLR4 in experimental anti-glomerular basement membrane (GBM) glomerulonephritis (GN). Anti-GBM GN was induced in tlr4

Indexed as

AnimalsBasement MembraneCytokinesFemaleGlomerulonephritisKidneyKidney GlomerulusMacrophagesMaleMiceMice, Inbred C57BLMyeloid CellsTh17 CellsTh1 CellsToll-Like Receptor 4CytokinesTlr4 protein, mouseToll-Like Receptor 4Anti-GBM crescentic glomerulonephritisMacrophagesMyeloid TLR4T cells

Identifiers

PMID34568976
PMCPMC8558180
OpenAlexW3204725176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.