ArticleEuropean heart journal. Cardiovascular Imaging2022
CArdiac MagnEtic resonance assessment of bi-Atrial fibrosis in secundum atrial septal defects patients: CAMERA-ASD study.
Article in European heart journal. Cardiovascular Imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Occupational stress, cardiovascular vulnerability and sudden cardiac death in police officers: mechanisms and the protective role of structured exercise.Frontiers in public health · 2026Review
- Atrial Septal Defect and Heart Rhythm Disorders: Physiopathological Linkage and Clinical Perspectives.Biomedicines · 2025Review
- Evaluation of bi-atrial dynamic electrophysiological properties in atrial septal defect patients.Frontiers in physiology · 2025Article
- Correlation between Epsilon Wave and Late Potentials in Arrhythmogenic Right Ventricular Cardiomyopathy-Do Late Potentials Define the Epsilon Wave?Journal of clinical medicine · 2024Article
- Electrocardiographic Characteristics in 438 Neonates with Atrial Septal Defects.Pediatric cardiology · 2024Observational
- Arrhythmic Risk and Treatment after Transcatheter Atrial Septal Defect Closure.Diagnostics (Basel, Switzerland) · 2023Review
- Right atrial function and fibrosis in relation to successful atrial fibrillation ablation.European heart journal. Cardiovascular Imaging · 2023Article
- Catheter ablation of atrial fibrillation using 2nd-generation cryoballoon in congenital heart disease patients - significance of RF ablation of additional atrial macro-reentrant tachycardia.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2022Article
- High-density mapping for AVNRT ablation with distorted conduction system anatomy post-ASD device closure-case report.Indian pacing and electrophysiology journalArticle
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
aimsAtrial septal defects (ASD) are associated with atrial arrhythmias, but the arrhythmia substrate in these patients is poorly defined. We hypothesized that bi-atrial fibrosis is present and that right atrial fibrosis is associated with atrial arrhythmias in ASD patients. We aimed to evaluate the extent of bi-atrial fibrosis in ASD patients and to investigate the relationships between bi-atrial fibrosis, atrial arrhythmias, shunt fraction, and age. METHODS AND
resultsPatients with uncorrected secundum ASDs (n = 36; 50.4 ± 13.6 years) underwent cardiac magnetic resonance imaging with atrial late gadolinium enhancement. Comparison was made to non-congenital heart disease patients (n = 36; 60.3 ± 10.5 years) with paroxysmal atrial fibrillation (AF). Cardiac magnetic resonance parameters associated with atrial arrhythmias were identified and the relationship between bi-atrial structure, age, and shunt fraction studied. Bi-atrial fibrosis burden was greater in ASD patients than paroxysmal AF patients (20.7 ± 14% vs. 10.1 ± 8.6% and 14.8 ± 8.5% vs. 8.6 ± 6.1% for right and left atria respectively, P = 0.001 for both). In ASD patients, right atrial fibrosis burden was greater in those with than without atrial arrhythmias (33.4 ± 18.7% vs. 16.8 ± 10.3%, P = 0.034). On receiver operating characteristic analysis, a right atrial fibrosis burden of 32% had a 92% specificity and 71% sensitivity for predicting the presence of atrial arrhythmias. Neither age nor shunt fraction was associated with bi-atrial fibrosis burden.
conclusionBi-atrial fibrosis burden is greater in ASD patients than non-congenital heart disease patients with paroxysmal AF. Right atrial fibrosis is associated with the presence of atrial arrhythmias in ASD patients. These findings highlight the importance of right atrial fibrosis to atrial arrhythmogenesis in ASD patients.
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