ArticleThe Lancet regional health. Western Pacific2021
The changing pattern of enteric pathogen infections in China during the COVID-19 pandemic: a nation-wide observational study.
Article in The Lancet regional health. Western Pacific, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 62 citations in OpenAlex.
- Epidemiological and Genotypic Trends of Enteric Adenovirus, Astrovirus, and Sapovirus in Gwangju, Korea, 2017-2023.Journal of Korean medical science · 2026Article
- Incidence of acute diarrhoea among children (0-59 months old) in Thailand after introduction of rotavirus vaccine: a retrospective national database analysis (2014-2024).The Lancet regional health. Southeast Asia · 2026Article
- Trends in incidence and DALYs of infectious disease from 2000 to 2023 and the attributable risk factors in China: an analysis of the Global Burden of Disease Study 2023.The Lancet regional health. Western Pacific · 2026Article
- Impact of the COVID-19 pandemic and typhoid conjugate vaccine introduction on typhoid fever in Nepal.PLoS neglected tropical diseases · 2026Article
- Co-infection and interaction of enteric pathogens in acute diarrhea among children under five years: a large-scale multicenter observational study from China.Infectious diseases of poverty · 2025Observational
- Foodborne disease outbreaks before and during the COVID-19 pandemic in Jiangsu Province, China.One health (Amsterdam, Netherlands) · 2025Article
- National trends in burden of enteric infections in China: Shifts from 1990 to 2021.Infectious medicine · 2025Article
- Insights Into Pandemic and Post-Pandemic Dynamics of Enteric Viruses in a Middle-Size City-Burgos, Spain-Using a Long-Term Wastewater Surveillance.Food and environmental virology · 2025Article
- Genomic insights into antibiotic-resistant non-typhoidal Salmonella isolates from outpatients in Minhang District in Shanghai.Communications medicine · 2025Article
- Changing patterns and biological features of community-acquiredMicrobiology spectrum · 2025Article
- Genetic and Antigenic Variability in VP4 and VP7 of Group A Human Rotavirus in Yunnan, China, from 2015 to 2020.Intervirology · 2025Article
- Epidemic characteristics and effectiveness of vaccine intervention on rotavirus infection: a real-world observational study in Zhejiang Province, China.Frontiers in public health · 2025Observational
- DiarrheagenicChina CDC weekly · 2024Article
- Article
- Impact of non-pharmaceutical interventions during the COVID-19 pandemic on pathogens transmitted via food in the Netherlands.Epidemiology and infection · 2024Article
- Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study.The Journal of infectious diseases · 2024Article
- Risk Factors forPathogens (Basel, Switzerland) · 2024Article
- Review
- Environmental Surveillance of Human Astroviruses in Jinan City of China, 2020-2021.Food and environmental virology · 2024Article
- [Impact of the pandemic on various infectious diseases with different epidemiological patterns of seasonality, transmission and age].Revista espanola de salud publica · 2024Article
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Authors and funding
24 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon pharmaceutical interventions (NPI) including hand washing directives were implemented in China and worldwide to combat the COVID-19 pandemic, which are likely to have had impacted a broad spectrum of enteric pathogen infections.
methodsEtiologically diagnostic data from 45 937 and 67 395 patients with acute diarrhea between 2012 and 2020, who were tested for seven viral pathogens and 13 bacteria respectively, were analyzed to assess the changes of enteric pathogen infections in China during the first COVID-19 pandemic year compared to pre-pandemic years.
findingsTest positive rates of all enteric viruses decreased during 2020, compared to the average levels during 2012-2019, with a relative decrease of 71•75% for adenovirus, 58•76% for norovirus, 53•50% for rotavirus A, and 72•07% for the combination of other four uncommon viruses. In general, a larger reduction of positive rate in viruses was seen among adults than pediatric patients. A rebound of rotavirus A was seen after September 2020 in North China rather than South China. Test positive rates of bacteria decreased during 2020, compared to the average levels during 2012-2019, excepting for nontyphoidal
interpretationThe activity of enteric pathogens changed profoundly alongside the NPIs implemented during the COVID-19 pandemic in China. Greater reductions of the test positive rates were found for almost all enteric viruses than for bacteria among acute diarrhea patients, with further large differences by age and geography. Lifting of NPIs will lead to resurgence of enteric pathogen infections, particularly in children whose immunity may not have been developed and/or waned.
fundingChina Mega-Project on Infectious Disease Prevention; National Natural Science Funds.
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