Evidence map›Paper›PMID 34568822›Full record

ArticleNAR genomics and bioinformatics2021

A combination of mRNA features influence the efficiency of leaderless mRNA translation initiation.

Mohammed-Husain M Bharmal, Alisa Gega, Jared M Schrader

Open access · goldAbstract read
In one paragraph

Article in NAR genomics and bioinformatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mohammed-Husain M BharmalDepartment of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
Alisa GegaDepartment of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
Jared M SchraderDepartment of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.ORCID https://orcid.org/0000-0002-5728-5882
Wayne State University · US

Funding

Mechanisms of Non-Shine-Dalgarno Translation InitiationR35GM124733 · NIGMS · WAYNE STATE UNIVERSITY · PI Jared Michael Schrader · 2017 to 2026
$3.6M
NIGMS NIH HHS R35 GM124733
6 · The paper itself

Abstract

Bacterial translation is thought to initiate by base pairing of the 16S rRNA and the Shine-Dalgarno sequence in the mRNA's 5' untranslated region (UTR). However, transcriptomics has revealed that leaderless mRNAs, which completely lack any 5' UTR, are broadly distributed across bacteria and can initiate translation in the absence of the Shine-Dalgarno sequence. To investigate the mechanism of leaderless mRNA translation initiation, synthetic

Identifiers

PMID34568822
PMCPMC8459731
OpenAlexW3174830318

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.