ArticleiScience2021
Single antibody detection in a DNA origami nanoantenna.
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Tunable DNA Origami Nanosensors for Detection of Multiscale Spatial Ion Concentration Gradients.ACS sensors · 2026Article
- Single-Molecule Detection Concepts Enabled by DNA Origami.Micromachines · 2026Review
- DNA Origami and Their Application in Biosensors.Biosensors · 2026Review
- Comprehensive Review on DNA Hydrogels and DNA Origami-Enabled Wearable and Implantable Biosensors.Biosensors · 2025Review
- Tunable DNA Origami Nanosensors for Detection of Multiscale Spatial Ion Concentration Gradients.bioRxiv : the preprint server for biology · 2025Article
- Single-Molecule Detection of Optical Signals Using DNA-Based Plasmonic Nanostructures.Biosensors · 2025Review
- Engineering modular and tunable single-molecule sensors by decoupling sensing from signal output.Nature nanotechnology · 2025Article
- DNA Origami Vesicle Sensors with Triggered Single-Molecule Cargo Transfer.Angewandte Chemie (International ed. in English) · 2024Article
- Controlled mechanochemical coupling of anti-junctions in DNA origami arrays.Nature communications · 2024Article
- DNA-Based Gold Nanoparticle Assemblies: From Structure Constructions to Sensing Applications.Sensors (Basel, Switzerland) · 2023Review
- Synthetic Antigen-Conjugated DNA Systems for Antibody Detection and Characterization.ACS sensors · 2023Review
- Article
- Lab-on-a-DNA origami: nanoengineered single-molecule platforms.Chemical communications (Cambridge, England) · 2023Review
- Gene-encoding DNA origami for mammalian cell expression.Nature communications · 2023Article
- Salting-Out of DNA Origami Nanostructures by Ammonium Sulfate.International journal of molecular sciences · 2022Article
- Stochastic modeling of antibody binding predicts programmable migration on antigen patterns.Nature computational science · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA nanotechnology offers new biosensing approaches by templating different sensor and transducer components. Here, we combine DNA origami nanoantennas with label-free antibody detection by incorporating a nanoswitch in the plasmonic hotspot of the nanoantenna. The nanoswitch contains two antigens that are displaced by antibody binding, thereby eliciting a fluorescent signal. Single-antibody detection is demonstrated with a DNA origami integrated anti-digoxigenin antibody nanoswitch. In combination with the nanoantenna, the signal generated by the antibody is additionally amplified. This allows the detection of single antibodies on a portable smartphone microscope. Overall, fluorescence-enhanced antibody detection in DNA origami nanoantennas shows that fluorescence-enhanced biosensing can be expanded beyond the scope of the nucleic acids realm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.