Evidence map›Paper›PMID 34568781›Full record

ArticleiScience2021

A persistent invasive phenotype in post-hypoxic tumor cells is revealed by fate mapping and computational modeling.

Heber L Rocha, Inês Godet, Furkan Kurtoglu, John Metzcar, Kali Konstantinopoulos, Soumitra Bhoyar, Daniele M Gilkes, Paul Macklin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

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  14. Mapping the Fate of Hypoxic Cells Using an Irreversible Fluorescent Switch.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Heber L RochaDepartment of Intelligent Systems Engineering, Indiana University, Bloomington, IN 47408, USA.
Inês GodetDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Furkan KurtogluDepartment of Intelligent Systems Engineering, Indiana University, Bloomington, IN 47408, USA.
John MetzcarDepartment of Intelligent Systems Engineering, Indiana University, Bloomington, IN 47408, USA.
Kali KonstantinopoulosDepartment of Intelligent Systems Engineering, Indiana University, Bloomington, IN 47408, USA.
Soumitra BhoyarDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Daniele M GilkesDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Paul MacklinDepartment of Intelligent Systems Engineering, Indiana University, Bloomington, IN 47408, USA.
Indiana University Bloomington · USJohns Hopkins University · US

Funding

Multiscale systems biology modeling to exploit tumor-stromal metabolic crosstalk in colorectal cancerU01CA232137 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINLEY, STACEY DELERIA, MACKLIN, PAUL T · 2018 to 2022
$2.8M
6 · The paper itself

Abstract

Hypoxia is a critical factor in solid tumors that has been associated with cancer progression and aggressiveness. We recently developed a hypoxia fate mapping system to trace post-hypoxic cells within a tumor for the first time. This approach uses an oxygen-dependent fluorescent switch and allowed us to measure key biological features such as oxygen distribution, cell proliferation, and migration. We developed a computational model to investigate the motility and phenotypic persistence of hypoxic and post-hypoxic cells during tumor progression. The cellular behavior was defined by phenotypic persistence time, cell movement bias, and the fraction of cells that respond to an enhanced migratory stimulus. This work combined advanced cell tracking and imaging techniques with mathematical modeling, to reveal that a persistent invasive migratory phenotype that develops under hypoxia is required for cellular escape into the surrounding tissue, promoting the formation of invasive structures ("plumes") that expand toward the oxygenated tumor regions.

Indexed as

CancerCancer systems biologyCell biologySystems biology

Identifiers

PMID34568781
PMCPMC8449249
OpenAlexW3190433214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.