Evidence map›Paper›PMID 34568720›Full record

ArticleJCO precision oncology2021

Spectrum of

M Herman Chui, Jason C Chang, Yanming Zhang, Ahmet Zehir, Alison M Schram, Jason Konner, Alexander E Drilon, Arnaud Da Cruz Paula, Britta Weigelt, Rachel N Grisham

Open access · bronzeAbstract read
In one paragraph

Article in JCO precision oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Gynecologic oncology reports · 2025
    Article
  4. Review
  5. Review
  6. Genomics of ovarian cancers and the potential of precision medicine.Therapeutic advances in medical oncology · 2025
    Review
  7. RareHeliyon · 2024
    Article
  8. Review
  9. Article
  10. MAPK Pathway Genetic Alterations Are Associated with Prolonged Overall Survival in Low-Grade Serous Ovarian Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

M Herman ChuiDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-7220-3996
Jason C ChangDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-1705-1870
Yanming ZhangDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.
Ahmet ZehirDepartment of Computational Biology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-5406-4104
Alison M SchramDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-6070-2413
Jason KonnerDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-0720-2719
Alexander E DrilonDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-6806-9061
Arnaud Da Cruz PaulaDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Britta WeigeltDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-9927-1270
Rachel N GrishamDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Low-grade serous carcinoma (LGSC) is a rare type of ovarian cancer, which commonly arises from serous borderline tumor (SBT) and is characterized by frequent activating mutations in the mitogen-activated protein kinase pathway, including

methodsRetrospective analysis of our institutional cohort of SBTs (n = 22), LGSCs (n = 119) and high-grade serous carcinomas (HGSCs, n = 1,290) subjected to targeted massively parallel sequencing was performed to identify cases with

results

conclusionRecognition of

Indexed as

CarcinomaOvarian NeoplasmsFemaleGene RearrangementHumansIn Situ Hybridization, FluorescenceMutationNeoplasm GradingProto-Oncogene Proteins B-rafRetrospective StudiesBRAF protein, humanProto-Oncogene Proteins B-raf

Identifiers

PMID34568720
PMCPMC8457847
OpenAlexW3199225385

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.