Evidence map›Paper›PMID 34568623›Full record

ArticleInternational journal of surgery open2021

Optic neuritis concomitant with pituitary macroadenoma in a patient with active COVID-19 infection: A case report.

Mohammed Maan Al-Salihi, Md Moshiur Rahman, Maryam Sabah Al-Jebur, Sabrina Rahman, Ivan David Lozada-Martinez, Raphia Rahman, Luis Rafael Moscote-Salazar

Open access · goldAbstract readCase Reports
In one paragraph

Article in International journal of surgery open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Effects of coronavirus disease 2019 in patients with optic neuritis: a single-centre retrospective cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Mohammed Maan Al-SalihiMedical Doctor College of Medicine. University of Baghdad, Baghdad, Iraq.
Md Moshiur RahmanDepartment of Neurosurgery, Holy Family Red Crescent Medical College, Dhaka, Bangladesh.
Maryam Sabah Al-JeburMedical Doctor College of Medicine. University of Baghdad, Baghdad, Iraq.
Sabrina RahmanDepartment of Public Health, Independent University-Bangladesh, Dhaka, Bangladesh.
Ivan David Lozada-MartinezMedical and Surgical Research Center, School of Medicine, University of Cartagena, Cartagena, Colombia.
Raphia RahmanRowan School of Osteopathic Medicine, Stratford, NJ, USA.
Luis Rafael Moscote-SalazarCenter for Biomedical Research (CIB), Faculty of Medicine, University of Cartagena, Cartagena, Colombia.
University of Baghdad · IQUniversity of Cartagena · COHoly Family Red Crescent Medical CollegeIndependent University · BDRowan University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction and importanceSeveral neuro-ophthalmic manifestations have been reported with coronavirus disease 2019 (COVID-19) infection. However, isolated optic neuritis was infrequently reported in humans with COVID-19. If it occurred, optic neuritis was usually a part of a demyelinating syndrome. CASE PRESENTATION: In this paper, we report a case of optic neuritis concomitant with an undiagnosed pituitary macroadenoma discovered during active COVID-19 infection. The case was a 33-year-old woman with infertility who was recently found to have a pituitary macroadenoma secreting prolactin. During active COVID-19 infection, the patient developed optic neuritis that responded well to corticosteroids. Brain imaging and hormonal profile negated the presence of any demyelinating disease or pituitary apoplexy. CLINICAL DISCUSSION: A dilemma of whether optic neuritis occurring concomitantly with pituitary macroadenoma is just a coincidence, or there is an association remains unresolved. Whether COVID-19 infection might precipitate optic neuritis in patients with pituitary macroadenoma or not remains an issue to be answered by observing data from future case reports about similar findings.

conclusionOptic neuritis in concomitant with pituitary macroadenoma following COVID-19 infection represents a dilemma of whether the visual symptoms are attributed to the tumor or COVID-19 infection.

Indexed as

COVID-19Optic neuritisPituitary macroadenoma

Identifiers

PMID34568623
PMCPMC8384762
OpenAlexW3195352752

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.