Evidence map›Paper›PMID 34568508›Full record

ArticleOrthopaedic journal of sports medicine2021

Effect of Demineralized Bone Matrix, Bone Marrow Mesenchymal Stromal Cells, and Platelet-Rich Plasma on Bone Tunnel Healing After Anterior Cruciate Ligament Reconstruction: A Comparative Micro-Computed Tomography Study in a Tendon Allograft Sheep Model.

Adam T Hexter, Aikaterina Karali, Alex Kao, Gianluca Tozzi, Nima Heidari, Aviva Petrie, Ashleigh Boyd, Deepak M Kalaskar, Catherine Pendegrass, Scott Rodeo and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedic journal of sports medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Adam T HexterDivision of Surgery and Interventional Science, University College London, London, UK.
Aikaterina KaraliZeiss Global Centre, School of Mechanical and Design Engineering, University of Portsmouth, Portsmouth, UK.
Alex KaoZeiss Global Centre, School of Mechanical and Design Engineering, University of Portsmouth, Portsmouth, UK.
Gianluca TozziZeiss Global Centre, School of Mechanical and Design Engineering, University of Portsmouth, Portsmouth, UK.
Nima HeidariRoyal London Hospital and Orthopaedic Specialists (OS), London, UK.
Aviva PetrieEastman Dental Institute, University College London, London, UK.
Ashleigh BoydDivision of Surgery and Interventional Science, University College London, London, UK.
Deepak M KalaskarDivision of Surgery and Interventional Science, University College London, London, UK.
Catherine PendegrassDivision of Surgery and Interventional Science, University College London, London, UK.
Scott RodeoHospital of Special Surgery, New York, New York, USA.
Fares HaddadUniversity College London Hospitals, London, UK.
Gordon BlunnSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.
University College London · GBUniversity of Portsmouth · GBRoyal London Hospital · GBEastman Dental Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe effect of demineralized bone matrix (DBM), bone marrow-derived mesenchymal stromal cells (BMSCs), and platelet-rich plasma (PRP) on bone tunnel healing in anterior cruciate ligament reconstruction (ACLR) has not been comparatively assessed. HYPOTHESIS: These orthobiologics would reduce tunnel widening, and the effects on tunnel diameter would be correlated with tunnel wall sclerosis. STUDY

designControlled laboratory study.

methodsA total of 20 sheep underwent unilateral ACLR using tendon allograft and outside-in interference screw fixation. The animals were randomized into 4 groups (n = 5 per group): Group 1 received 4mL of DBM paste, group 2 received 10 million BMSCs in fibrin sealant, group 3 received 12 mL of activated leukocyte-poor platelet-rich plasma, and group 4 (control) received no treatment. The sheep were euthanized after 12 weeks, and micro-computed tomography scans were performed. The femoral and tibial tunnels were divided into thirds (aperture, midportion, and exit), and the trabecular bone structure, bone mineral density (BMD), and tunnel diameter were measured. Tunnel sclerosis was defined by a higher bone volume in a 250-µm volume of interest compared with a 4-mm volume of interest surrounding the tunnel.

resultsCompared with the controls, the DBM group had a significantly higher bone volume fraction (bone volume/total volume [BV/TV]) (52.7% vs 31.8%;

conclusionOnly DBM led to a significant increase in bone volume, which was seen in the femoral tunnel aperture and midportion. No treatment significantly reduced bone tunnel widening. Tunnel sclerosis in the femoral tunnel midportion was correlated significantly with tunnel widening. CLINICAL RELEVANCE: DBM might have potential clinical use to enhance healing in the femoral tunnel after ACLR.

Indexed as

anterior cruciate ligament (ACL) reconstructionbiological modulationbone marrow–derived mesenchymal stromal cell (BMSC)demineralized bone matrix (DBM)microcomputed tomographyplatelet-rich plasma (PRP)

Identifiers

PMID34568508
PMCPMC8461134
OpenAlexW3179310096

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.