Evidence map›Paper›PMID 34568494›Full record

ArticleBioMed research international2021

Ropivacaine-Loaded Poloxamer Binary Hydrogels for Prolonged Regional Anesthesia: Structural Aspects, Biocompatibility, and Pharmacological Evaluation.

Kelli Cristina Freitas Mariano, Juliana Zampoli Boava Papini, Naially Cardoso de Faria, Daniele Nicoli Cabral Heluany, Ana Luiza Lourençoni Botega, Cíntia Maria Saia Cereda, Eneida de Paula, Giovana Radomille Tófoli, Daniele Ribeiro de Araujo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Kelli Cristina Freitas MarianoHuman and Natural Sciences Center, Federal University of ABC, Santo André, SP, Brazil.
Juliana Zampoli Boava PapiniSão Leopoldo Mandic Faculty, São Leopoldo Mandic Research Institute, Campinas, São Paulo, Brazil.
Naially Cardoso de FariaFederal University of São Paulo, Translational Medicine Postgraduate Program, São Paulo, Brazil.
Daniele Nicoli Cabral HeluanySão Leopoldo Mandic Faculty, São Leopoldo Mandic Research Institute, Campinas, São Paulo, Brazil.
Ana Luiza Lourençoni BotegaSão Leopoldo Mandic Faculty, São Leopoldo Mandic Research Institute, Campinas, São Paulo, Brazil.
Cíntia Maria Saia CeredaSão Leopoldo Mandic Faculty, São Leopoldo Mandic Research Institute, Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-0893-4564
Eneida de PaulaDepartment of Biochemistry, State University of Campinas, Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-4504-5723
Giovana Radomille TófoliSão Leopoldo Mandic Faculty, São Leopoldo Mandic Research Institute, Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-6403-7708
Daniele Ribeiro de AraujoHuman and Natural Sciences Center, Federal University of ABC, Santo André, SP, Brazil.ORCID https://orcid.org/0000-0002-9289-4229
Faculdade São Leopoldo Mandic · BRUniversidade Federal do ABC · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study reports the development of thermosensitive hydrogels for delivering ropivacaine (RVC), a wide clinically used local anesthetic. For this purpose, poloxamer- (PL-) based hydrogels were synthesized for evaluating the influence of polymer concentration, hydrophilic-lipophilic balances, and binary system formation on biopharmaceutical properties and pharmacological performance. Transition temperatures were shifted, and rheological analysis revealed a viscoelastic behavior with enhanced elastic/viscous modulus relationship (

Indexed as

Anesthesia, Local3T3 CellsAnalgesiaAnimalsArea Under CurveBiocompatible MaterialsCalorimetry, Differential ScanningCell DeathCell SurvivalDrug LiberationElasticityHydrogelsMaleMiceMicellesPoloxamerBiocompatible MaterialsHydrogelsMicellesPoloxamerRopivacaine

Identifiers

PMID34568494
PMCPMC8460376
OpenAlexW3199333941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.