Evidence map›Paper›PMID 34568333›Full record

ReviewFrontiers in cell and developmental biology2021

Critical Considerations for the Design of Multi-Organ Microphysiological Systems (MPS).

Mridu Malik, Yang Yang, Parinaz Fathi, Gretchen J Mahler, Mandy B Esch

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Frontiers in immunology · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Pumped and pumpless microphysiological systems to study (nano)therapeutics.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mridu MalikDepartment of Bioengineering, University of Maryland, College Park, College Park, MD, United States.
Yang YangBiophysical and Biomedical Measurement Group, Physical Measurement Laboratory, Microsystems and Nanotechnology Division, National Institute of Standards and Technology, Gaithersburg, MD, United States.
Parinaz FathiDepartment of Bioengineering, Materials Science and Engineering, and Beckman Institute, University of Illinois at Urbana-Champaign, Champaign, IL, United States.
Gretchen J MahlerDepartment of Biomedical Engineering, Binghamton University, Binghamton, NY, United States.
Mandy B EschBiophysical and Biomedical Measurement Group, Physical Measurement Laboratory, Microsystems and Nanotechnology Division, National Institute of Standards and Technology, Gaithersburg, MD, United States.

Funding

Engineering a Small Intestinal Microbiome to Evaluate Food Additive ExposureR01ES028788 · NIEHS · STATE UNIVERSITY OF NY,BINGHAMTON · PI MAHLER, GRETCHEN, MARQUES, CLAUDIA N.H. · 2018 to 2022
$1.5M
NIEHS NIH HHS R01 ES028788
6 · The paper itself

Abstract

Identification and approval of new drugs for use in patients requires extensive preclinical studies and clinical trials. Preclinical studies rely on

Indexed as

body-on-a-chipmicrofluidicsmicrophysiological systemsMPSorgan-on-a-chip

Identifiers

PMID34568333
PMCPMC8459628

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.