Evidence map›Paper›PMID 34568330›Full record

ArticleFrontiers in cell and developmental biology2021

Adipose/Connective Tissue From Thyroid-Associated Ophthalmopathy Uncovers Interdependence Between Methylation and Disease Pathogenesis: A Genome-Wide Methylation Analysis.

Yu Liang, Sijia Ding, Xiying Wang, Chunchun Hu, Yihan Zhang, Yan Hu, Yuye Zhang, Hongyu Kong, Weiyi Xia, Qinghe Jing and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Yu LiangEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Sijia DingDepartment of Phase 1 Clinical Trial Unit, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Xiying WangEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Chunchun HuEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Yihan ZhangEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Yan HuEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Yuye ZhangEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Hongyu KongEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Weiyi XiaEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Qinghe JingEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Yuxiang HuEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Chen ZhaoEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Lianqun WuEye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNEye & ENT Hospital of Fudan University · CNFudan University · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In response to pathological stimulation, methylation status conversion of the genome drives changes of cell feature and is able to promote disease development. Yet the role of methylation in the development of thyroid-associated ophthalmopathy (TAO) remains to be evaluated. Overexpansion of orbital tissue is the key feature of TAO. In this study, the methylation profile of orbital adipose/connective tissue from TAO patients and normal individuals were compared. After screening 3,739 differentially methylated probes, the distribution and properties of these probes were analyzed. Furthermore, enriched biological functions of these genes associated with differential methylation and the relationship between their methylation status and expression profile were also identified, including PTPRU and VCAM-1. According to our results, methylation was involved in disregulated immune response and inflammation in TAO and might contribute to activation of fibroblast and adipogenesis, leading to the expansion of orbital tissue. Neuropathy and neurobehavioral symptoms were also potentially associated with methylation. These results may help to extend the understanding of methylation in TAO and provide more insights into diagnosis and treatment of patients.

Indexed as

methylationmethylation arrayorbital adipose/connective tissuepathologythyroid-associated ophthalmopathy

Identifiers

PMID34568330
PMCPMC8457400
OpenAlexW3197237081

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.