Evidence map›Paper›PMID 34568285›Full record

ArticleFrontiers in chemistry2021

Design of Experiments for Matrix-Assisted Laser Desorption/Ionization of Amphiphilic Poly(Ethylene Oxide)-b-Polystyrene Block Copolymers.

Hélène Pizzala, Magalie Claeys-Bruno, Valérie Monnier, Michelle Sergent, Laurence Charles

Open access · goldAbstract read
In one paragraph

Article in Frontiers in chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Hélène PizzalaAix Marseille Université, CNRS, UMR 7273, Institut de Chimie Radicalaire, Marseille, France.
Magalie Claeys-BrunoAix Marseille Université, UMR CNRS IRD 7263, Institut Méditerranéen de Biodiversité Marine et Continentale, Marseille, France.
Valérie MonnierAix Marseille Université, CNRS, Centrale Marseille, FR 1739, Fédérations des Sciences Chimiques, Marseille, France.
Michelle SergentAix Marseille Université, UMR CNRS IRD 7263, Institut Méditerranéen de Biodiversité Marine et Continentale, Marseille, France.
Laurence CharlesAix Marseille Université, CNRS, UMR 7273, Institut de Chimie Radicalaire, Marseille, France.
Centre National de la Recherche Scientifique · FRCentrale Marseille · FRInstitut de Chimie Radicalaire · FRInstitut de Recherche pour le Développement · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Matrix-assisted laser/desorption ionization (MALDI) has become a very popular ionization technique for mass spectrometry of synthetic polymers because it allows high throughput analysis of low amounts of sample while avoiding the complexity introduced by extensive multiple charging of electrospray ionization. Yet, fundamental mechanisms underlying this ionization process are not fully understood, so development of sample preparation methods remains empirical. Reliable prediction for the optimal matrix/analyte/salt system is indeed still not possible for homopolymers and it becomes even more challenging in the case of amphiphilic block copolymers where conditions dictated by one block are not compatible with MALDI requirements of the second block. In order to perform MALDI of copolymers composed of poly (ethylene oxide) (PEO) and polystyrene (PS) blocks, it was postulated here that experimental conditions suitable for both species would also be successful for PEO-

Indexed as

amphiphilic copolymersdesign of experimentsMALDImass spectrometryQSARspace filling design

Identifiers

PMID34568285
PMCPMC8458736
OpenAlexW3197970169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.