Evidence map›Paper›PMID 34568098›Full record

ArticleFrontiers in cellular and infection microbiology2021

S100B Inhibition Attenuates Intestinal Damage and Diarrhea Severity During

Deiziane V S Costa, Vivaldo Moura-Neto, David T Bolick, Richard L Guerrant, Jibraan A Fawad, Jae H Shin, Pedro H Q S Medeiros, Solanka E Ledwaba, Glynis L Kolling, Conceição S Martins and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 34 citations in OpenAlex.

  1. CSPG4 Mediates Inflammatory, Cell Death, and Senescence Responses in Enteric Glia Exposed to Clostridioides difficile Toxins.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. In Vitro Manipulation of Gene Expression in Enteric Glial Cells.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  4. Review
  5. Rodent Enteric Glia Culture.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. iMetaOmics · 2025
    Review
  12. The Physiology of Enteric Glia.Annual review of physiology · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Clinical microbiology reviews · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Deiziane V S CostaDepartment of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
Vivaldo Moura-NetoPaulo Niemeyer Brain Institute, Federal University of Rio de Janeiro, UFRJ, Rio de Janeiro, Brazil.
David T BolickDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, United States.
Richard L GuerrantDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, United States.
Jibraan A FawadDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, United States.
Jae H ShinDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, United States.
Pedro H Q S MedeirosDepartment of Microbiology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
Solanka E LedwabaDepartment of Biochemistry and Microbiology, Faculty of Science, Engineering and Agriculture, University of Venda, Thohoyandou, South Africa.
Glynis L KollingDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, United States.
Conceição S MartinsDepartment of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
Venkat VenkataramanDepartment of Cell Biology and Neuroscience, Rowan University School of Osteopathic Medicine, Stratford, NJ, United States.
Cirle A WarrenDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, United States.
Gerly A C BritoDepartment of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
University of Virginia · USUniversidade Federal do Ceará · BRRowan University · USUniversidade Federal do Rio de Janeiro · BRUniversity of Venda · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The involvement of the enteric nervous system, which is a source of S100B, in

Indexed as

Bacterial ToxinsClostridioides difficileClostridium InfectionsAnimalsBacterial ProteinsClostridioidesDiarrheaHumansMiceRatsS100 Calcium Binding Protein beta SubunitSuppressor of Cytokine Signaling ProteinsBacterial ProteinsBacterial ToxinsS100B protein, humanS100b protein, mouseS100b protein, ratS100 Calcium Binding Protein beta SubunitSocs2 protein, ratSuppressor of Cytokine Signaling ProteinsClostridioides difficilediarrheaenteric gliainflammationS100B

Identifiers

PMID34568098
PMCPMC8461106
OpenAlexW3199675376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.