Evidence map›Paper›PMID 34568096›Full record

ArticleFrontiers in cellular and infection microbiology2021

The Development of Ovine Gastric and Intestinal Organoids for Studying Ruminant Host-Pathogen Interactions.

David Smith, Daniel R G Price, Alison Burrells, Marc N Faber, Katie A Hildersley, Cosmin Chintoan-Uta, Ambre F Chapuis, Mark Stevens, Karen Stevenson, Stewart T G Burgess and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 83 citations in OpenAlex.

  1. Animal organoids as models for integrated One Health research.One health (Amsterdam, Netherlands) · 2026
    Review
  2. Applied and environmental microbiology · 2026
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  7. Article
  8. Identification ofFrontiers in veterinary science · 2026
    Article
  9. Functional characteristics of a pig 2D intestinal organoid model as anJournal of animal science and technology · 2026
    Article
  10. Review
  11. In vitro co-culture ofVirulence · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. eLife · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Cryopreservation of neuroectoderm on a pillar plate andbioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

David SmithDepartment of Disease Control, Moredun Research Institute, Midlothian, United Kingdom.
Daniel R G PriceDepartment of Vaccines and Diagnostics, Moredun Research Institute, Midlothian, United Kingdom.
Alison BurrellsDepartment of Disease Control, Moredun Research Institute, Midlothian, United Kingdom.
Marc N FaberDepartment of Disease Control, Moredun Research Institute, Midlothian, United Kingdom.
Katie A HildersleyDepartment of Disease Control, Moredun Research Institute, Midlothian, United Kingdom.
Cosmin Chintoan-UtaThe Roslin Institute, University of Edinburgh, Midlothian, United Kingdom.
Ambre F ChapuisDepartment of Vaccines and Diagnostics, Moredun Research Institute, Midlothian, United Kingdom.
Mark StevensThe Roslin Institute, University of Edinburgh, Midlothian, United Kingdom.
Karen StevensonDepartment of Vaccines and Diagnostics, Moredun Research Institute, Midlothian, United Kingdom.
Stewart T G BurgessDepartment of Vaccines and Diagnostics, Moredun Research Institute, Midlothian, United Kingdom.
Elisabeth A InnesDepartment of Disease Control, Moredun Research Institute, Midlothian, United Kingdom.
Alasdair J NisbetDepartment of Vaccines and Diagnostics, Moredun Research Institute, Midlothian, United Kingdom.
Tom N McNeillyDepartment of Disease Control, Moredun Research Institute, Midlothian, United Kingdom.
Moredun Research Institute · GBRoslin Institute · GBUniversity of Edinburgh · GB

Funding

Biotechnology and Biological Sciences Research Council BB/P013740/1Biotechnology and Biological Sciences Research Council BBS/E/D/20002173
6 · The paper itself

Abstract

Gastrointestinal (GI) infections in sheep have significant implications for animal health, welfare and productivity, as well as being a source of zoonotic pathogens. Interactions between pathogens and epithelial cells at the mucosal surface play a key role in determining the outcome of GI infections; however, the inaccessibility of the GI tract

Indexed as

IntestinesOrganoidsAnimalsHost-Pathogen InteractionsRuminantsSheepStomachcryptsgastrointestinalhost-pathogen interactionsin vitro culture systemsmini-gutssheepstem cellsthree-dimensional (3D) organoids

Identifiers

PMID34568096
PMCPMC8456012
OpenAlexW3198647108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.