Evidence map›Paper›PMID 34567788›Full record

ArticleRegenerative biomaterials2021

The effect of macropore size of hydroxyapatite scaffold on the osteogenic differentiation of bone mesenchymal stem cells under perfusion culture.

Feng Shi, Dongqin Xiao, Chengdong Zhang, Wei Zhi, Yumei Liu, Jie Weng

Open access · goldAbstract read
In one paragraph

Article in Regenerative biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Fabrication and Characterization of a Porous TiOACS biomaterials science & engineering · 2025
    Article
  3. Article
  4. [Application and progress of intelligent responsive hydrogels in articular cartilage injury repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Recent advances in regenerative biomaterials.Regenerative biomaterials · 2022
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Feng ShiCollaboration Innovation Center for Tissue Repair Material Engineering Technology, College of Life Science, China West Normal University, No.1 Shida Road, Nanchong, Sichuan 637002, China.
Dongqin XiaoResearch Institute of Tissue Engineering and Stem Cells, Nanchong Central Hospital, the Second Clinical College of North Sichuan Medical College, No.97 Renmin South Road, Nanchong, Sichuan 637000, China.
Chengdong ZhangResearch Institute of Tissue Engineering and Stem Cells, Nanchong Central Hospital, the Second Clinical College of North Sichuan Medical College, No.97 Renmin South Road, Nanchong, Sichuan 637000, China.
Wei ZhiCollege of Medicine, Southwest Jiaotong University, No.111 North 1st Section of Second Ring Road, Chengdu, Sichuan 610031, China.
Yumei LiuCollaboration Innovation Center for Tissue Repair Material Engineering Technology, College of Life Science, China West Normal University, No.1 Shida Road, Nanchong, Sichuan 637002, China.
Jie WengCollege of Medicine, Southwest Jiaotong University, No.111 North 1st Section of Second Ring Road, Chengdu, Sichuan 610031, China.
Southwest Jiaotong University · CNChina West Normal University · CNNanchong Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have proved that dynamic culture could facilitate nutrients transport and apply mechanical stimulation to the cells within three-dimensional scaffolds, thus enhancing the differentiation of stem cells towards the osteogenic phenotype. However, the effects of macropore size on osteogenic differentiation of stem cells under dynamic condition are still unclear. Therefore, the objective of this study was to investigate the effects of macropore size of hydroxyapatite (HAp) scaffolds on osteogenic differentiation of bone mesenchymal stem cells under static and perfusion culture conditions.

Indexed as

HAp scaffoldsmacropore sizeosteogenic differentiationperfusion culture

Identifiers

PMID34567788
PMCPMC8457200
OpenAlexW3197096054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.