ArticleMicrosystems & nanoengineering2020
Modular operation of microfluidic chips for highly parallelized cell culture and liquid dosing via a fluidic circuit board.
Article in Microsystems & nanoengineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- A Plug-and-Play Volume Minimizing Micromixer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- STARTER: a stand-alone reconfigurable and translational organ-on-chip platform based on modularity and open design principles.Lab on a chip · 2026Article
- Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs-On-Chips.Advanced biology · 2026Review
- ML-automated microfluidic circuit design.Science advances · 2026Article
- Development of Stimuli-Responsive Polymeric Nanomedicines in Hypoxic Tumors and Their Therapeutic Promise in Oral Cancer.Polymers · 2025Review
- Low-Cost, Open-Source, High-Precision Pressure Controller for Multi-Channel Microfluidics.Biosensors · 2025Article
- Organoids-on-a-chip: microfluidic technology enables culture of organoids with enhanced tissue function and potential for disease modeling.Frontiers in bioengineering and biotechnology · 2025Review
- A Miniature Modular Fluorescence Flow Cytometry System.Biosensors · 2024Article
- Establishment and evaluation of on-chip intestinal barrier biosystems based on microfluidic techniques.Materials today. Bio · 2024Review
- A Modular Microfluidic Organoid Platform Using LEGO-Like Bricks.Advanced healthcare materials · 2024Article
- A programmable microfluidic platform to monitor calcium dynamics in microglia during inflammation.Microsystems & nanoengineering · 2024Article
- Cell Culture Model Evolution and Its Impact on Improving Therapy Efficiency in Lung Cancer.Cancers · 2023Review
- An outlook on the current challenges and opportunities in DNA data storage.Biotechnology advances · 2023Review
- Wrinkled Thermo-Electric Meander-Shaped Element on a Thin Freestanding PDMS Membrane.Membranes · 2023Article
- Microfluidic Impedance Cytometry for Single-Cell Particulate Inorganic Carbon:Particulate Organic Carbon Measurements of Calcifying Algae.Global challenges (Hoboken, NJ) · 2023Article
- Nanoparticle Printing for Microfluidic Applications: Bipolar Electrochemistry and Localized Raman Sensing Spots.Micromachines · 2023Article
- Multiplexed fluidic circuit board for controlled perfusion of 3D blood vessels-on-a-chip.Lab on a chip · 2022Article
- Article
- Rubik's Cube as Reconfigurable Microfluidic Platform for Rapid Setup and Switching of Analytical Devices.Micromachines · 2022Article
- The VersaLive platform enables microfluidic mammalian cell culture for versatile applications.Communications biology · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microfluidic systems enable automated and highly parallelized cell culture with low volumes and defined liquid dosing. To achieve this, systems typically integrate all functions into a single, monolithic device as a "one size fits all" solution. However, this approach limits the end users' (re)design flexibility and complicates the addition of new functions to the system. To address this challenge, we propose and demonstrate a modular and standardized plug-and-play fluidic circuit board (FCB) for operating microfluidic building blocks (MFBBs), whereby both the FCB and the MFBBs contain integrated valves. A single FCB can parallelize up to three MFBBs of the same design or operate MFBBs with entirely different architectures. The operation of the MFBBs through the FCB is fully automated and does not incur the cost of an extra external footprint. We use this modular platform to control three microfluidic large-scale integration (mLSI) MFBBs, each of which features 64 microchambers suitable for cell culturing with high spatiotemporal control. We show as a proof of principle that we can culture human umbilical vein endothelial cells (HUVECs) for multiple days in the chambers of this MFBB. Moreover, we also use the same FCB to control an MFBB for liquid dosing with a high dynamic range. Our results demonstrate that MFBBs with different designs can be controlled and combined on a single FCB. Our novel modular approach to operating an automated microfluidic system for parallelized cell culture will enable greater experimental flexibility and facilitate the cooperation of different chips from different labs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.