ArticleMicrosystems & nanoengineering2020
Bioinspired microcone-array-based living biointerfaces: enhancing the anti-inflammatory effect and neuronal network formation.
Article in Microsystems & nanoengineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Silicon Carbide Neural Interfaces: A Review of Progress Toward Monolithic Devices.Nanomaterials (Basel, Switzerland) · 2025Review
- Bio-inspired electronics: Soft, biohybrid, and "living" neural interfaces.Nature communications · 2025Review
- Advances in novel biomaterials combined with traditional Chinese medicine rehabilitation technology in treatment of peripheral nerve injury.Frontiers in neurology · 2024Review
- Rational Fabrication of Ag Nanocone Arrays Embedded with Ag NPs and Their Sensing Applications.ACS omega · 2022Article
- A silk-based self-adaptive flexible opto-electro neural probe.Microsystems & nanoengineering · 2022Article
- Electrochemical and biological performance of hierarchical platinum-iridium electrodes structured by a femtosecond laser.Microsystems & nanoengineering · 2022Article
- Bio-integrative design of the neural tissue-device interface.Current opinion in biotechnology · 2021Review
- A FlexibleMicromachines · 2021Article
- Editing the Shape Morphing of Monocomponent Natural Polysaccharide Hydrogel Films.Research (Washington, D.C.) · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implantable neural interfaces and systems have attracted much attention due to their broad applications in treating diverse neuropsychiatric disorders. However, obtaining a long-term reliable implant-neural interface is extremely important but remains an urgent challenge due to the resulting acute inflammatory responses. Here, bioinspired microcone-array-based (MA) interfaces have been successfully designed, and their cytocompatibility with neurons and the inflammatory response have been explored. Compared with smooth control samples, MA structures cultured with neuronal cells result in much denser extending neurites, which behave similar to creepers, wrapping tightly around the microcones to form complex and interconnected neuronal networks. After further implantation in mouse brains for 6 weeks, the MA probes (MAPs) significantly reduced glial encapsulation and neuron loss around the implants, suggesting better neuron viability at the implant-neural interfaces than that of smooth probes. This bioinspired strategy for both enhanced glial resistance and neuron network formation via a specific structural design could be a platform technology that not only opens up avenues for next-generation artificial neural networks and brain-machine interfaces but also provides universal approaches to biomedical therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.