ArticleMicrosystems & nanoengineering2020
An aptamer-based shear horizontal surface acoustic wave biosensor with a CVD-grown single-layered graphene film for high-sensitivity detection of a label-free endotoxin.
Article in Microsystems & nanoengineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A Metamaterial Buckling-Assisted Surface-Acoustic-Wave Enabled Sensor (mBASES) for Versatile and Ultrasensitive Biomarker Detection.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Acoustofluidic Biosensors.Micromachines · 2026Review
- Advances in Bio-Microelectromechanical System-Based Sensors for Next-Generation Healthcare Applications.ACS omega · 2025Review
- Review
- Advances in MEMS, Optical MEMS, and Nanophotonics Technologies for Volatile Organic Compound Detection and Applications.Small science · 2025Review
- Novel Aptamer Strategies in Combating Bacterial Infections: From Diagnostics to Therapeutics.Pharmaceutics · 2024Review
- Simultaneous Detection of Exosomal microRNAs Isolated from Cancer Cells Using Surface Acoustic Wave Sensor Array with High Sensitivity and Reproducibility.Micromachines · 2024Article
- Review
- Challenges for Field-Effect-Transistor-Based Graphene Biosensors.Materials (Basel, Switzerland) · 2024Review
- The Recent Development of Acoustic Sensors as Effective Chemical Detecting Tools for Biological Cells and Their Bioactivities.Molecules (Basel, Switzerland) · 2023Review
- Aerosol jet printing of piezoelectric surface acoustic wave thermometer.Microsystems & nanoengineering · 2023Article
- Article
- Acoustic Biosensors and Microfluidic Devices in the Decennium: Principles and Applications.Micromachines · 2021Review
- Evaluation of Shear Horizontal Surface Acoustic Wave Biosensors Using "Layer Parameter" Obtained from Sensor Responses during Immunoreaction.Sensors (Basel, Switzerland) · 2021Article
- Aptamer-based biosensors for the diagnosis of sepsis.Journal of nanobiotechnology · 2021Review
- Recent Advances in Nanomaterial-Based Aptasensors in Medical Diagnosis and Therapy.Nanomaterials (Basel, Switzerland) · 2021Review
- Acoustic radiation-free surface phononic crystal resonator for in-liquid low-noise gravimetric detection.Microsystems & nanoengineering · 2021Article
- Biosensors Based on Mechanical and Electrical Detection Techniques.Sensors (Basel, Switzerland) · 2020Review
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8 authors.
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Abstract
The thickness of the sensitive layer has an important influence on the sensitivity of a shear horizontal surface acoustic wave (SH-SAW) biosensor with a delay-line structure and lower layer numbers of graphene produce better sensitivity for biological detection. Therefore, a label-free and highly sensitive SH-SAW biosensor with chemical vapor deposition (CVD-)-grown single-layered graphene (SLG) for endotoxin detection was developed in this study. With this methodology, SH-SAW biosensors were fabricated on a 36° Y-90° X quartz substrate with a base frequency of 246.2 MHz, and an effective detection cell was fabricated using acrylic material. To increase the surface hydrophilicity, chitosan was applied to the surface of the SLG film. Additionally, the aptamer was immobilized on the surface of the SLG film by cross-linking with glutaraldehyde. Finally, the sensitivity was verified by endotoxin detection with a linear detection ranging from 0 to 100 ng/mL, and the detection limit (LOD) was as low as 3.53 ng/mL. In addition, the stability of this type of SH-SAW biosensor from the air phase to the liquid phase proved to be excellent and the specificity was tested and verified by detecting the endotoxin obtained from Escherichia coli (E. coli), the endotoxin obtained from Pseudomonas aeruginosa (P. aeruginosa), and aflatoxin. Therefore, this type of SH-SAW biosensor with a CVD-grown SLG film may offer a promising approach to endotoxin detection, and it may have great potential in clinical applications.
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