ArticleAcute medicine & surgery
Accidental hypothermia: characteristics, outcomes, and prognostic factors-A nationwide observational study in Japan (Hypothermia study 2018 and 2019).
Article in Acute medicine & surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Incidences of underlying causes of hypothermia in older patients in the emergency department: a systematic review.European geriatric medicine · 2023Pooled it
- Accidental hypothermia.Nature reviews. Disease primers · 2026Review
- Review
- Factors related to 30-day survival rate following accidental hypothermia - a retrospective single-center study from Northern Finland.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- Association of Carboxyhemoglobin With Severity and Outcomes in Hypothermic Patients: A Retrospective Cohort Study.Cureus · 2025Article
- Article
- Indications for extracorporeal membrane oxygenation in older adult patients with accidental hypothermia and hemodynamic instability.BMC emergency medicine · 2025Observational
- Extracorporeal cardiopulmonary resuscitation in hypothermic cardiac arrest: A secondary analysis of multicenter extracorporeal cardiopulmonary resuscitation registry data in Japan.Resuscitation plus · 2024Article
- Low-flow time and outcomes in hypothermic cardiac arrest patients treated with extracorporeal cardiopulmonary resuscitation: a secondary analysis of a multi-center retrospective cohort study.Journal of intensive care · 2024Article
- Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2023Article
- Possible adaptation measures for climate change in preventing heatstroke among older adults in Japan.Frontiers in public health · 2023Article
- External validation of 5A score model for predicting in-hospital mortality among the accidental hypothermia patients: JAAM-Hypothermia study 2018-2019 secondary analysis.Journal of intensive care · 2022Article
- Hypothermia-associated acute pancreatitis: A multicenter prospective observational study.Acute medicine & surgeryArticle
- Successfully treated case of severe hypothermia secondary to myxedema coma.Acute medicine & surgeryArticle
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Authors and funding
18 authors at 15 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study describes the clinical characteristics and outcomes as well as the prognostic factors of patients with accidental hypothermia (AH) using Japan's nationwide registry data.
methodsThe Hypothermia study 2018 and 2019, which included patients aged 18 years or older with a body temperature of 35°C or less, was a multicenter registry conducted at 87 and 89 institutions throughout Japan, with data collected from December 2018 to February 2019 and December 2019 to February 2020, respectively.
resultsIn total, 1363 patients were enrolled in the registry, of which 1194 were analyzed in this study. The median (interquartile range) age was 79 (68-87) years, and the median (interquartile range) body temperature at the emergency department was 30.8°C (28.4-33.6°C). Forty-three percent of patients with AH had a mild condition, 35.2% moderate, and 21.9% severe. AH occurred in an indoor setting in 73.4% and was caused by acute medical illness in 49.3% of patients. A total of 101 (8.5%) patients suffered from cardiopulmonary arrest on arrival at the hospital. The overall 30-day mortality rate was 24.5%, the median (interquartile range) intensive care unit stay was 4 (2-7) days, and the median (interquartile range) hospital stay was 13 (4-27) days. In the multivariable logistic analysis, the prognostic factors were age (≥75 years old), male, activities of daily living (needing total assistance), cause of AH (trauma, alcohol), Glasgow Coma Scale score, and potassium level (>5.5 mEq/L).
conclusionThe mortality rate of AH was 24.5% in Japan. The prognostic factors developed in this study may be useful for the early prediction, prevention, and awareness of severe AH.
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