Evidence map›Paper›PMID 34567455›Full record

ReviewJournal of community hospital internal medicine perspectives2021

Hemophagocytic lymph histiocytosis (HLH): etiologies, pathogenesis, treatment, and outcomes in critically ill patients: a review article and literature to review.

Mohsin Mirza, Maryam Zafar, Joseph Nahas, Wafa Arshad, Anum Abbas, Abubakar Tauseef

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of community hospital internal medicine perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Mohsin MirzaInternal Medicine Department, Creighton University Hospital Program, Omaha, NE, USA.
Maryam ZafarInternal Medicine Department, Dow University of Health Sciences, DUHS, Karachi, Pakistan.
Joseph NahasInternal Medicine Department, Creighton University Hospital Program, Omaha, NE, USA.
Wafa ArshadInternal Medicine Department, Dow University of Health Sciences, DUHS, Karachi, Pakistan.
Anum AbbasInternal Medicine Department, University of Nebraska Medical Center, Omaha, USA.
Abubakar TauseefInternal Medicine Department, Creighton University Hospital Program, Omaha, NE, USA.
Creighton University · USDow University of Health Sciences · PKUniversity of Nebraska Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemophagocytic lymph histiocytosis (HLH) is not an independent disease but is instead a clinical syndrome that occurs in many underlying conditions involving all age groups. HLH is the consequence of a severe, uncontrolled hyperinflammatory reaction that in most cases is triggered by an infectious agent. Acquired HLH is much more common than primary HLH syndrome but primary is more fatal, and it does have the worst prognosis with no definitive treatment available to date. This review article mentioned all the latest advancements regarding etiologies, pathogenesis, treatment, and outcomes in critically ill patients who got diagnosed with HLH syndrome in last 15 years.

Indexed as

diagnosisetiologiesHemophagocyticlymph histiocytosispathogenesisreviewtreatment

Identifiers

PMID34567455
PMCPMC8462863
OpenAlexW3198917772

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.