Evidence map›Paper›PMID 34567441›Full record

ArticleEuropean journal of psychotraumatology2021

Association between childhood trauma and brain anatomy in women with post-traumatic stress disorder, women with borderline personality disorder, and healthy women.

Catarina Rosada, Martin Bauer, Sabrina Golde, Sophie Metz, Stefan Roepke, Christian Otte, Oliver T Wolf, Claudia Buss, Katja Wingenfeld

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of psychotraumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Neurological soft signs in borderline personality disorder and schizophrenia.Borderline personality disorder and emotion dysregulation · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Catarina RosadaCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Klinik Für Psychiatrie Und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany.ORCID 0000-0003-1977-0307
Martin BauerCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität Zu Berlin, and Berlin Institute of Health, Institute of Medical Psychology, Berlin, Germany.ORCID 0000-0002-3120-7405
Sabrina GoldeClinical Psychology and Psychotherapy, Department of Education and Psychology, Freie Universität, Berlin, Germany.ORCID 0000-0002-6119-3323
Sophie MetzCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Klinik Für Psychiatrie Und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany.ORCID 0000-0003-3646-6665
Stefan RoepkeCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Klinik Für Psychiatrie Und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany.ORCID 0000-0003-3165-8684
Christian OtteCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Klinik Für Psychiatrie Und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany.ORCID 0000-0002-4051-997X
Oliver T WolfDepartment of Cognitive Psychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, Bochum, Germany.ORCID 0000-0002-9320-2124
Claudia BussCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität Zu Berlin, and Berlin Institute of Health, Institute of Medical Psychology, Berlin, Germany.ORCID 0000-0002-8738-3133
Katja WingenfeldCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Klinik Für Psychiatrie Und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany.ORCID 0000-0001-7457-0370

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Childhood trauma (CT) is associated with altered brain anatomy. These neuroanatomical changes might be more pronounced in individuals with a psychiatric disorder. Post-traumatic stress disorder (PTSD) and borderline personality disorder (BPD) are more prevalent in individuals with a history of CT. Objective: In this study, we examined limbic and total brain volumes in healthy women with and without a history of CT and in females with PTSD or BPD and a history of CT to see whether neuroanatomical changes are a function of psychopathology or CT. Method: In total, 128 women ( Results: Volume of the total brain, hippocampus, and amygdala did not differ between the four groups Conclusions: CT was associated with reduced brain volume but PTSD or BPD was not. The association between CT and reduced brain volume as a global measure of brain integrity suggests a common origin for vulnerability to psychiatric disorders later in life.

Indexed as

Adverse Childhood ExperiencesAdultBorderline Personality DisorderBrainChildFemaleHippocampusHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingPsychopathologyStress Disorders, Post-TraumaticSurveys and QuestionnairesAmígdalaamygdalaborderline personality disorderChildhood traumaHipocampohippocampusMRIpost-traumatic stress disorderRNMTrastorno de Estrés PostraumáticoTrastorno de Personalidad LimítrofeTrauma infantil创伤后应激障碍杏仁核海马童年期创伤边缘型人格障碍

Identifiers

PMID34567441
PMCPMC8462923

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.