Evidence map›Paper›PMID 34567349›Full record

ArticleThe World Allergy Organization journal2021

Hypertensive disorders of pregnancy and risk of allergic conditions in children: Findings from the Japan Environment and Children's study (JECS).

Limin Yang, Miori Sato, Mayako Saito-Abe, Makoto Irahara, Minaho Nishizato, Hatoko Sasaki, Mizuho Konishi, Kazue Ishitsuka, Hidetoshi Mezawa, Kiwako Yamamoto-Hanada and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The World Allergy Organization journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Global Modelling Links Maternal Hypertensive Disorders to Early Childhood Allergic Disease Burden.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2024
    Article
  3. Review
  4. Article
  5. Hypertensive disorders of pregnancy: definition, management, and out-of-office blood pressure measurement.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Limin YangAllergy Center, National Center for Child Health and Development, Tokyo, Japan.
Miori SatoAllergy Center, National Center for Child Health and Development, Tokyo, Japan.
Mayako Saito-AbeAllergy Center, National Center for Child Health and Development, Tokyo, Japan.
Makoto IraharaAllergy Center, National Center for Child Health and Development, Tokyo, Japan.
Minaho NishizatoAllergy Center, National Center for Child Health and Development, Tokyo, Japan.
Hatoko SasakiAllergy Center, National Center for Child Health and Development, Tokyo, Japan.
Mizuho KonishiAllergy Center, National Center for Child Health and Development, Tokyo, Japan.
Kazue IshitsukaAllergy Center, National Center for Child Health and Development, Tokyo, Japan.
Hidetoshi MezawaAllergy Center, National Center for Child Health and Development, Tokyo, Japan.
Kiwako Yamamoto-HanadaAllergy Center, National Center for Child Health and Development, Tokyo, Japan.
Kenji MatsumotoAllergy Center, National Center for Child Health and Development, Tokyo, Japan.
Yukihiro OhyaAllergy Center, National Center for Child Health and Development, Tokyo, Japan.
Japan Environment and Children's Study (JECS) Group
National Center For Child Health and Development · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypertensive disorders of pregnancy (HDP) are one of the most common medical conditions that women encounter during pregnancy. Whether or not hypertensive disorders of pregnancy (HDP) are associated with allergic conditions in the offspring is unclear. This study used data from a large Japanese birth cohort to investigate whether HDP contributes to the development of allergic conditions in the offspring at 3 years. We also assessed the effect of blood pressure at different pregnancy trimesters on children's allergies.

methodsWe obtained data from the Japan Environment and Children's Study (JECS), which included 104 062 fetal records. After data selection, we analyzed 77 505 mother-child pairs, using logistic regression models to examine the relationships between HDP or the mother's blood pressure and their children's allergic conditions. In addition, we also evaluated the effect of HDP during pregnancy on allergies with a propensity score matched dataset, using a logistic regression model that predicts the conditional probability of whether a mother belonged to the HDP or non-HDP group.

resultsAmong the 77 505 mothers eligible for analysis, 2334 (3.0%) had HDP. Percentages of women with hypertension were 1.7% in early gestation, 1.0% in mid-gestation, and 1.6% in late gestation. After adjusting for multiple potential confounders, HDP contributed nothing to allergy development in offspring. Children born to women with hypertension were no more likely than those without to have allergic conditions at 3 years of age. The propensity score matched dataset showed similar findings.

conclusionHDP and high blood pressure during pregnancy are apparently not risk factors for developing allergy in offspring. This information may help clinicians in counseling women who suffered HDP during pregnancy.

Indexed as

Birth cohortBlood pressureChildrenHypertensive disorders of pregnancyPregnancy

Identifiers

PMID34567349
PMCPMC8436168
OpenAlexW3200577246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.