Evidence map›Paper›PMID 34567126›Full record

ReviewInternational journal of otolaryngology2021

Sinonasal Tissue Remodelling during Chronic Rhinosinusitis.

Satya Amirapu, Kristi Biswas, Fiona J Radcliff, Brett Wagner Mackenzie, Stephen Ball, Richard G Douglas

Abstract readReview
In one paragraph

Review in International journal of otolaryngology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Impact of Early Versus Delayed Functional Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyps.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. [Research progress of type 2 inflammation-related tissue remodeling in nasal polyps].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Satya AmirapuDepartment of Surgery, The University of Auckland, Auckland 2043, New Zealand.ORCID https://orcid.org/0000-0002-8947-4557
Kristi BiswasDepartment of Surgery, The University of Auckland, Auckland 2043, New Zealand.ORCID https://orcid.org/0000-0001-6202-3898
Fiona J RadcliffDepartment of Molecular Medicine and Pathology, The University of Auckland, Auckland 2043, New Zealand.ORCID https://orcid.org/0000-0003-2679-6927
Brett Wagner MackenzieDepartment of Surgery, The University of Auckland, Auckland 2043, New Zealand.ORCID https://orcid.org/0000-0002-5318-1808
Stephen BallDepartment of Surgery, The University of Auckland, Auckland 2043, New Zealand.ORCID https://orcid.org/0000-0002-5804-4466
Richard G DouglasDepartment of Surgery, The University of Auckland, Auckland 2043, New Zealand.ORCID https://orcid.org/0000-0002-2900-0384

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this review is to summarise contemporary knowledge of sinonasal tissue remodelling during chronic rhinosinusitis (CRS), a chronic disease involving long-term inflammation of the paranasal sinuses and nasal passage. The concept of tissue remodelling has significant clinical relevance because of its potential to cause irreversibility in chronic airway tissues. Recent studies have indicated that early surgical treatment of CRS may improve clinical outcome. Tissue remodelling has been described in the literature extensively with no consensus on how remodelling is defined. This review describes various factors implicated in establishing remodelling in sinonasal tissues with a special mention of asthma as a comorbid condition. Some of the main histological features of remodelling include basement membrane thickening and collagen modulation. This may be an avenue of research with regard to targeted therapy against remodelling in CRS.

Identifiers

PMID34567126
PMCPMC8460364

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.