ReviewInternational journal of biomaterials2021
Local Drug Delivery Systems for Vital Pulp Therapy: A New Hope.
Review in International journal of biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- MG132 facilitates dentin regeneration by modulating inflammation and odontoblast differentiation.Cell and tissue research · 2026Article
- Article
- Intranasal delivery of engineered extracellular vesicles promotes neurofunctional recovery in traumatic brain injury.Journal of nanobiotechnology · 2025Article
- Local drug delivery for regeneration and disinfection in endodontics: A narrative review.Journal of conservative dentistry and endodontics · 2025Review
- Effect of Manipulation Methods and Storage Environments on the Microstructural, Chemical, and Mechanical Properties of Calcium-Enriched Mixture Cement.International journal of biomaterials · 2025Article
- Letter to the Editor, "Platelet-Rich Fibrin as a Novel Bio-Carrier for the Transfer of Antibiotics to the Root Canal System".Frontiers in dentistry · 2025Article
- A Critical Review of the Role of Geristore® in Contemporary Endodontics.Iranian endodontic journal · 2025Review
- Effect of Vital Pulp Therapy Biomaterials on Tooth Discolouration: A Review of the Literature.International journal of biomaterials · 2025Review
- Novel Fast-Setting and Mechanically-Strong Calcium Phosphate Pulp-Capping Cement with Metformin Release to Enhance Dental Pulp Stem Cells.Bioengineering (Basel, Switzerland) · 2024Article
- Tissue response and expression of interleukins (IL)-1ß, IL-6, IL-10 after pulp capping with bioglasses in mice.Brazilian oral research · 2024Article
- Beyond Tradition: Non-surgical Endodontics and Vital Pulp Therapy as a Dynamic Combination.Cureus · 2023Review
- Challenging the Misnomer of Irreversible Pulpitis and Deliberating the Urgent Need for Reclassification of Pulpal Diseases Based on the Efficacy of Vital Pulp Therapies: An Overview of Systematic Reviews.Iranian endodontic journal · 2023Review
- Healing of Large Endodontic Lesions Using Long-Term Application of a New Combination of Triple Antibiotics: A Series of Cases.Case reports in dentistry · 2023Article
- Pulp Therapy of Primary Dentition; its Relevance despite Insufficient Histological Evidence: A Review.Iranian endodontic journal · 2023Review
- Healing of large endodontic lesions using a new combination of triple antibiotics: A case report.Clinical case reports · 2023Article
- Anti-Inflammatory and Mineralization Effects of an ASP/PLGA-ASP/ACP/PLLA-PLGA Composite Membrane as a Dental Pulp Capping Agent.Journal of functional biomaterials · 2022Article
- Evaluating the Effect of Tideglusib-Loaded Bioactive Glass Nanoparticles as a Potential Dentine Regenerative Material.Materials (Basel, Switzerland) · 2022Article
- Effects of Intracanal Curcumin and Aloe vera on pH Changes in Simulated Root Surface Resorption Defects: AnIranian endodontic journal · 2022Article
- Human Treated Dentin Matrix Hydrogel as a Drug Delivery Scaffold for Regenerative Endodontics.Iranian endodontic journal · 2022Article
- Management of External Inflammatory Root Resorption following Tooth Autotransplantation Using a Modified Combination of Triple Antibiotics.Case reports in dentistry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vital pulp therapy (VPT) is deliberated as an ultraconservative/minimally invasive approach for the conservation of vital pulpal tissues, preservation of dental structure, and maintenance of tooth function in the oral cavity. In VPT, following the exposure of the dental pulp, the environment is prepared for the possible healing and probable refunctionalisation of pulpal connective tissue. However, to succeed in VPT, specific biomaterials are used to cover and/or dress the exposed pulp, lower the inflammation, heal the dental pulp, provoke the remaining odontoblastic cells, and induce the formation of a hard tissue, i.e., the dentinal bridge. It can be assumed that if the employed biomaterial is transferred to the target site using a specially designed micro-/nanosized local drug delivery system (LDDS), the biomaterial would be placed in closer proximity to the connective tissue, may be released in a controlled and sustained pattern, could properly conserve the remaining dental pulp and might appropriately enhance hard-tissue formation. Furthermore, the loaded LDDS could help VPT modalities to be more ultraconservative and may minimise the manipulation of the tooth structure as well as pulpal tissue, which could, in turn, result in better VPT outcomes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.