Evidence map›Paper›PMID 34566993›Full record

ArticleFrontiers in immunology2021

HLA-G1

Joseph Sushil Rao, Nora Hosny, Ramesh Kumbha, Raza Ali Naqvi, Amar Singh, Zachary Swanson, Heather Levy, Anders W Matson, Magie Steinhoff, Nicole Forneris and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  3. Cytotoxic Responses Mediated by NK Cells and Cytotoxic T Lymphocytes in Xenotransplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2025
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  7. Enhanced Insulin Production From Porcine Islets: More Insulin, Less Islets.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  8. Pig Xenotransplantation in Beta Cell Replacement: Addressing Challenges and Harnessing Potential for Type 1 Diabetes Therapy.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Joseph Sushil RaoDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Nora HosnyDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Ramesh KumbhaDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Raza Ali NaqviDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Amar SinghDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Zachary SwansonDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Heather LevyDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Anders W MatsonDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Magie SteinhoffDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Nicole FornerisDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Eric WaltersIndependent Consultant, Centralia, MO, United States.
Bernhard J HeringDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Christopher BurlakDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
University of Minnesota · USCentralia College · USSuez Canal University · EG

Funding

Resource Core for National Swine Resource and Research Center (NSRRC) Years 21-25U42OD011140 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI Kiho Lee, Kevin Dale Wells · 2012 to 2026
$26.7M
NIH HHS U42 OD011140
6 · The paper itself

Abstract

The human leukocyte antigen G1 (HLA-G1), a non-classical class I major histocompatibility complex (MHC-I) protein, is a potent immunomodulatory molecule at the maternal/fetal interface and other environments to regulate the cellular immune response. We created GGTA1

Indexed as

AnimalsAnimals, Genetically ModifiedBlood GlucoseB-LymphocytesCell ProliferationCells, CulturedCoculture TechniquesFibroblastsGalactosyltransferasesGenotypeHaplorhiniHLA-G AntigensHumansInterferon-gammaIslets of Langerhans TransplantationKiller Cells, Naturalalpha-1,3-galactosyltransferase 1, porcineBlood GlucoseGalactosyltransferasesHLA-G AntigensIFNG protein, humanInterferon-gammaCRIPSR/Cas9HLAG-1isletporcinexenotransplantation

Identifiers

PMID34566993
PMCPMC8459615
OpenAlexW3199500448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.