Evidence map›Paper›PMID 34566986›Full record

ArticleFrontiers in immunology2021

CD49a Identifies Polyfunctional Memory CD8 T Cell Subsets that Persist in the Lungs After Influenza Infection.

Emma C Reilly, Mike Sportiello, Kris Lambert Emo, Andrea M Amitrano, Rakshanda Jha, Ashwin B R Kumar, Nathan G Laniewski, Hongmei Yang, Minsoo Kim, David J Topham

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Monocyte-derived galectin-1Nature immunology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Resident CD49aScience advances · 2026
    Article
  7. Origins of CD8 tissue resident memory.Frontiers in immunology · 2026
    Review
  8. Light Metabolically Reprograms CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Differential predictive value of resident memory CD8Journal for immunotherapy of cancer · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Emma C ReillyCenter for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.
Mike SportielloCenter for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.
Kris Lambert EmoCenter for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.
Andrea M AmitranoCenter for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.
Rakshanda JhaCenter for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.
Ashwin B R KumarCenter for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.
Nathan G LaniewskiCenter for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.
Hongmei YangDepartment of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, United States.
Minsoo KimCenter for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.
David J TophamCenter for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.
University of Rochester Medical Center · US

Funding

Tissue regulation of T cell function - Reagents CoreP01AI102851 · NIAID · UNIVERSITY OF ROCHESTER · PI Iwijn De Vlaminck · 2014 to 2026
$26.0M
University of Rochester Mentoring Environment: Nurturing Training Opportunities in Research (UR-MENTOR)T32GM007356 · NIGMS · UNIVERSITY OF ROCHESTER · PI O'BANION, M. KERRY · 1985 to 2023
$15.1M
MULTIDISCIPLINARY TRAINING IN PULMONARY RESEARCHT32HL066988 · NHLBI · UNIVERSITY OF ROCHESTER · PI GEORAS, STEVE N, O'REILLY, MICHAEL A · 2001 to 2021
$8.1M
The T32 Predoctoral Training Program in Immunology (PTPI)T32AI007285 · NIAID · UNIVERSITY OF ROCHESTER · PI Scott Andrew Gerber, JACQUES Robert · 1986 to 2026
$7.6M
NHLBI NIH HHS T32 HL066988NIAID NIH HHS P01 AI102851NIAID NIH HHS T32 AI007285NIGMS NIH HHS T32 GM007356
6 · The paper itself

Abstract

CD8 T cell memory offers critical antiviral protection, even in the absence of neutralizing antibodies. The paradigm is that CD8 T cell memory within the lung tissue consists of a mix of circulating T

Indexed as

Immunologic MemoryAlphainfluenzavirusAnimalsCD8-Positive T-LymphocytesCells, CulturedChemokinesCytotoxicity, ImmunologicDisease Models, AnimalGranulocyte-Macrophage Colony-Stimulating FactorHost-Pathogen InteractionsIntegrin alpha1KineticsLungMaleMemory T CellsMiceChemokinesGranulocyte-Macrophage Colony-Stimulating FactorIntegrin alpha1CD103CD49aCD8 T cellsinfluenza A viruspolyfunctionalityresident memory TRMviral immunology

Identifiers

PMID34566986
PMCPMC8462271
OpenAlexW3201565139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.