ArticleFrontiers in immunology2021
FHR-5 Serum Levels and
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Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Functional Characterization of a Novel Intronic Complement Factor I Variant in Factor I Deficiency and Atypical Hemolytic Uremic Syndrome.Kidney international reports · 2026Article
- Primary membranoproliferative glomerulonephritis: natural history, pathogenesis, and treatment.Frontiers in nephrology · 2026Review
- Autoantibodies Against Factor B and Factor H Without Pathogenic Effects in a Patient with Immune Complex-Mediated Membranoproliferative Glomerulonephritis.Biomedicines · 2025Article
- Factor H-related 1 and heparan sulfate architecture contribute to complement dysregulation in C3 glomerulopathy.Frontiers in immunology · 2025Article
- The complement factor H-related protein-5 (CFHR5) exacerbates pathological bone formation in ankylosing spondylitis.Journal of molecular medicine (Berlin, Germany) · 2024Article
- Complement dysregulation associated with a genetic variant in factor H-related protein 5 in atypical hemolytic uremic syndrome.Pediatric nephrology (Berlin, Germany) · 2024Article
- Article
- Protein-centric omics analysis reveals circulating complements linked to non-viral liver diseases as potential therapeutic targets.Clinical and molecular hepatology · 2024Article
- Genetic investigation of Nordic patients with complement-mediated kidney diseases.Frontiers in immunology · 2023Article
- The Factor H protein family: The switchers of the complement alternative pathway.Immunological reviews · 2023Review
- C3 glomerulopathy: Understanding an ultra-rare complement-mediated renal disease.American journal of medical genetics. Part C, Seminars in medical genetics · 2022Review
- Levels of soluble complement regulators predict severity of COVID-19 symptoms.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
68 authors at 20 institutions in 12 countries.
Nóra GaramDepartment of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.
Marcell CserhalmiMTA-ELTE Complement Research Group, Eötvös Loránd Research Network (ELKH), Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.
Zoltán ProhászkaDepartment of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.
Ágnes SzilágyiDepartment of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.
Nóra VeszeliDepartment of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.
Edina SzabóDepartment of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.
Barbara UzonyiDepartment of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.
Attila IliásDepartment of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.
Christof AignerDivision of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Alice SchmidtDivision of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Martina GagglDivision of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Gere Sunder-PlassmannDivision of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Dóra Bajcsi1st Department of Internal Medicine, University of Szeged, Szeged, Hungary.
Jürgen BrunnerDepartment of Pediatrics, Medical University of Innsbruck, Innsbruck, Austria.
Alexandra DumfarthDepartment of Medicine III: Nephrology, Transplant Medicine and Rheumatology, Geriatric Department, Ordensklinikum Linz-Elisabethinen, Linz, Austria.
Daniel CejkaDepartment of Medicine III: Nephrology, Transplant Medicine and Rheumatology, Geriatric Department, Ordensklinikum Linz-Elisabethinen, Linz, Austria.
Stefan FlaschbergerHospital of Klagenfurt, Klagenfurt, Austria.
Hana FlögelovaDivision of Nephrology, Department of Pediatrics, Faculty of Medicine, Palacky University and Faculty Hospital in Olomouc, Olomouc, Czechia.
Ágnes HarisDepartment of Nephrology, Péterfy Hospital, Budapest, Hungary.
Ágnes HartmannDepartment of Pediatrics, University of Pécs, Pécs, Hungary.
Andreas HeilosDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Nephrology and Gastroenterology, Medical University of Vienna, Vienna, Austria.
Thomas MuellerDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Nephrology and Gastroenterology, Medical University of Vienna, Vienna, Austria.
Krisztina RusaiDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Nephrology and Gastroenterology, Medical University of Vienna, Vienna, Austria.
Klaus ArbeiterDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Nephrology and Gastroenterology, Medical University of Vienna, Vienna, Austria.
Johannes HoferDepartment of Pediatrics, Medical University of Innsbruck, Innsbruck, Austria.
Dániel JakabDepartment of Pediatrics, University of Szeged, Szeged, Hungary.
Mária SinkóDepartment of Pediatrics, University of Szeged, Szeged, Hungary.
Erika SzigetiDepartment of Pediatrics, University of Szeged, Szeged, Hungary.
Csaba BereczkiDepartment of Pediatrics, University of Szeged, Szeged, Hungary.
Viktor JankoMedimpax, Bratislava, Slovakia.
Kata Kelen1st Department of Pediatrics, Semmelweis University, Budapest, Hungary.
György S Reusz1st Department of Pediatrics, Semmelweis University, Budapest, Hungary.
Attila J Szabó1st Department of Pediatrics, Semmelweis University, Budapest, Hungary.
Nóra KlenkFresenius Medical Care (FMC) Center of Dialysis, Miskolc, Hungary.
Krisztina KóborFresenius Medical Care (FMC) Center of Dialysis, Miskolc, Hungary.
Nika KojcInstitute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Maarten KnechtelsdorferDepartment of Nephrology, Wilhelminenspital, Vienna, Austria.
Mario LaganovicDepartment of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia.
Adrian Catalin LunguPediatric Nephrology Department, Fundeni Clinical Institute, Bucharest, Romania.
Anamarija MeglicDepartment of Pediatric Nephrology, Division of Pediatrics, University Medical Center Ljubljana, Ljubljana, Slovenia.
Rina RusDepartment of Pediatric Nephrology, Division of Pediatrics, University Medical Center Ljubljana, Ljubljana, Slovenia.
Tanja Kersnik LevartDepartment of Pediatric Nephrology, Division of Pediatrics, University Medical Center Ljubljana, Ljubljana, Slovenia.
Ernesta MacionieneNephrology Center, Santaros Klinikos, Medical Faculty, Vilnius University, Vilnius, Lithuania.
Marius MiglinasNephrology Center, Santaros Klinikos, Medical Faculty, Vilnius University, Vilnius, Lithuania.
Anna PawłowskaDepartment of Nephrology, Hypertension and Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
Tomasz StompórDepartment of Nephrology, Hypertension and Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
Ludmila PodrackaDepartment of Pediatrics, Comenius University, Bratislava, Slovakia.
Michael RudnickiDepartment of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Innsbruck, Austria.
Gert MayerDepartment of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Innsbruck, Austria.
Romana RysavaNephrology Clinic, 1st Faculty of Medicine, Charles University, Prague, Czechia.
Jana ReiterovaNephrology Clinic, 1st Faculty of Medicine, Charles University, Prague, Czechia.
Marijan SaragaDepartment of Pediatrics, University Hospital Split, Split, Croatia.
Tomáš SeemanDepartment of Pediatrics, 2nd Faculty of Medicine, Charles University Prague, University Hospital Motol, Pragu, Czechia.
Jakub ZiegDepartment of Pediatrics, 2nd Faculty of Medicine, Charles University Prague, University Hospital Motol, Pragu, Czechia.
Eva SládkováDepartment of Pediatrics, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czechia.
Natasa StajicInstitute of Mother and Childhealth Care of Serbia "Dr Vukan Čupić", Belgrade, Serbia.
Tamás SzabóDepartment of Pediatrics, Faculty of Medicine, Debrecen University, Debrecen, Hungary.
Andrei CapitanescuCarol Davila Nephrology Hospital, Bucharest, Romania.
Simona StancuCarol Davila Nephrology Hospital, Bucharest, Romania.
Miroslav TisljarDepartment of Nephrology, University Hospital Dubrava Zagreb, Zagreb, Croatia.
Kresimir GalesicDepartment of Nephrology, University Hospital Dubrava Zagreb, Zagreb, Croatia.
András TislérDepartment of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary.
Inga VainumäeDepartment of Pathology, Tartu University Hospital, Tartu, Estonia.
Martin WindpesslInternal Medicine IV, Section of Nephrology, Klinikum Wels-Grieskirchen, Wels, Austria.
Tomas ZaoralDepartment of Pediatrics, University Hospital and Faculty of Medicine, Ostrava, Czechia.
Galia ZlatanovaUniversity Children's Hospital, Medical University, Sofia, Bulgaria.
Mihály JózsiMTA-ELTE Complement Research Group, Eötvös Loránd Research Network (ELKH), Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.
Dorottya CsukaDepartment of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.
Semmelweis University · HUMedical University of Vienna · ATCharles University · CZUniversity of Szeged · HUEötvös Loránd University · HUInnsbruck Medical University · ATLjubljana University Medical Centre · SICarol Davila University of Medicine and Pharmacy · ROKrankenhaus der Elisabethinen · ATUniversity Hospital Dubrava · HRUniversity of Warmia and Mazury in Olsztyn · PLVilnius University · LTComenius University Bratislava · SKHungarian Research NetworkInstitute of Public Health of Serbia · RSInstitutul Clinic Fundeni · ROKlinikum Klagenfurt · ATKlinikum Wels-Grieskirchen · ATMedical University of Sofia · BGMedirex Group Academy · SK
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Factor H-related protein 5 (FHR-5) is a member of the complement Factor H protein family. Due to the homology to Factor H, the main complement regulator of the alternative pathway, it may also be implicated in the pathomechanism of kidney diseases where Factor H and alternative pathway dysregulation play a role. Here, we report the first observational study on Methods: A total of 120 patients with a histologically proven diagnosis of IC-MPGN/C3G were enrolled in the study. FHR-5 serum levels were measured in ELISA, the Results: Eight exonic Conclusions: Our observations raise the possibility that the FHR-5 protein plays a fine-tuning role in the pathogenesis of IC-MPGN/C3G.
Indexed as
BiomarkersGenetic VariationAdolescentAdultAllelesAntigen-Antibody ComplexCase-Control StudiesComplement ActivationComplement C3Complement System ProteinsDisease ManagementDisease SusceptibilityEnzyme-Linked Immunosorbent AssayFemaleGenetic Predisposition to DiseaseGlomerulonephritis, MembranoproliferativeAntigen-Antibody ComplexBiomarkersCFHR5 protein, humanComplement C3Complement System ProteinsC3 glomerulonephritis (C3GN)C3 glomerulopathydense deposit disease (DDD)immune complex-mediated glomerulonephritismembranoproliferative glomerulonephritis
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