Evidence map›Paper›PMID 34566969›Full record

ArticleFrontiers in immunology2021

Hepatitis B Vaccine Non-Responders Show Higher Frequencies of CD24

Nina Körber, Laureen Pohl, Birgit Weinberger, Beatrix Grubeck-Loebenstein, Andrea Wawer, Percy A Knolle, Hedwig Roggendorf, Ulrike Protzer, Tanja Bauer

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Nina KörberInstitute of Virology, Helmholtz Zentrum München, Munich, Germany.
Laureen PohlInstitute of Virology, Helmholtz Zentrum München, Munich, Germany.
Birgit WeinbergerInstitute for Biomedical Aging Research, Universität Innsbruck, Innsbruck, Austria.
Beatrix Grubeck-LoebensteinInstitute for Biomedical Aging Research, Universität Innsbruck, Innsbruck, Austria.
Andrea WawerOccupational Health Unit, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
Percy A KnolleGerman Center for Infection Research (DZIF), Munich, Germany.
Hedwig RoggendorfGerman Center for Infection Research (DZIF), Munich, Germany.
Ulrike ProtzerInstitute of Virology, Helmholtz Zentrum München, Munich, Germany.
Tanja BauerInstitute of Virology, Helmholtz Zentrum München, Munich, Germany.
Helmholtz Zentrum München · DETechnical University of Munich · DEUniversität Innsbruck · ATGerman Center for Infection Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The cellular mechanisms involved in the lack of protective antibody response after hepatitis B vaccination are still rather unclear. Regulatory B cells (Breg) known as modulators of B-and T-cell responses may contribute to poor vaccine responsiveness. The current study aimed to investigate the role of regulatory B cells (Breg) in hepatitis B vaccine non-responsiveness after immunization with second- or third-generation hepatitis B vaccines. Method: We performed comparative phenotypic and frequency analysis of Breg subsets (CD24 Results: Flow cytometry-based analyses revealed elevated frequencies of CD24 Conclusion: Here we report significantly higher frequencies of CD24

Indexed as

Gene ExpressionLymphocyte CountADP-ribosyl Cyclase 1B-Lymphocytes, RegulatoryB-Lymphocyte SubsetsCD24 AntigenFemaleFlow CytometryHepatitis BHepatitis B AntibodiesHepatitis B VaccinesHepatitis B virusHost-Pathogen InteractionsHumansInterleukin-10MaleADP-ribosyl Cyclase 1CD24 AntigenCD24 protein, humanCD38 protein, humanHepatitis B AntibodiesHepatitis B VaccinesIL10 protein, humanInterleukin-10Membrane GlycoproteinsB10+ cellshepatitis B vaccinationIL-10 expressionregulatory B cellsvaccine non-responsiveness

Identifiers

PMID34566969
PMCPMC8461011
OpenAlexW3201329222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.