Evidence map›Paper›PMID 34566945›Full record

ArticleFrontiers in microbiology2021

Sanguinarine Inhibits the 2-Ketogluconate Pathway of Glucose Utilization in

Federica A Falchi, Giorgia Borlotti, Francesco Ferretti, Gianvito Pellegrino, Matteo Raneri, Marco Schiavoni, Alessandro Caselli, Federica Briani

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Sanguinarine Protects Channel Catfish againstPathogens (Basel, Switzerland) · 2022
    Article
  7. Review
  8. Preclinical safety evaluation ofFrontiers in pharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Federica A FalchiDipartimento di Bioscienze, Università degli Studi di Milano, Milan, Italy.
Giorgia BorlottiDipartimento di Bioscienze, Università degli Studi di Milano, Milan, Italy.
Francesco FerrettiDipartimento di Chimica, Università degli Studi di Milano, Milan, Italy.
Gianvito PellegrinoDipartimento di Bioscienze, Università degli Studi di Milano, Milan, Italy.
Matteo RaneriDipartimento di Bioscienze, Università degli Studi di Milano, Milan, Italy.
Marco SchiavoniDipartimento di Chimica, Università degli Studi di Milano, Milan, Italy.
Alessandro CaselliDipartimento di Chimica, Università degli Studi di Milano, Milan, Italy.
Federica BrianiDipartimento di Bioscienze, Università degli Studi di Milano, Milan, Italy.
University of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interfering with the ability of pathogenic bacteria to import glucose may represent a new promising antibacterial strategy, especially for the treatment of infections occurring in diabetic and other hyperglycemic patients. Such patients are particularly susceptible to infections caused by a variety of bacteria, among which opportunistic pathogens like

Indexed as

antibacterial drug discoverybacterial infections in hyperglycemic patientsdrug repurposingglucose catabolismPrestwick Chemical LibraryPseudomonas aeruginosasanguinarine

Identifiers

PMID34566945
PMCPMC8461315
OpenAlexW3200135819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.