ArticleFrontiers in endocrinology2021
Lowered Serum Testosterone Concentration Is Associated With Enhanced Inflammation and Worsened Lipid Profile in Men.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 49 citations in OpenAlex.
- Association between a novel nutritional-inflammatory index and testosterone levels: a cross-sectional study.Sexual medicine · 2026Article
- Pre-Diagnostic Plasma Endogenous Steroids and the Risk of Exfoliation Glaucoma.Investigative ophthalmology & visual science · 2026Article
- System-level clustering of testosterone-related biomarkers identifies high-risk aging profiles linked to inflammation and renal function.Communications medicine · 2026Article
- Pre-diagnostic plasma endogenous steroids and the risk of exfoliation glaucoma.medRxiv : the preprint server for health sciences · 2026Article
- Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives.International journal of molecular sciences · 2026Review
- Testosterone-related indices and adverse glucose-lipid metabolic status in men: a single-center retrospective study.Frontiers in endocrinology · 2026Article
- Association between ultra-processed foods intake and frailty risk in community-dwelling older adults.Journal of health, population, and nutrition · 2025Article
- Current perspectives on the pathogenesis of cerebral atherosclerosis.Journal of inflammation (London, England) · 2025Review
- Association Between Dietary Intake of Omega-3 Fatty Acids and Serum Testosterone in Adult Males: Results From NHANES 2011-2016 and 2021-2023.Food science & nutrition · 2025Article
- Association between circulatory immune cell to high-density lipoprotein cholesterol ratios and testosterone level in adult men: findings from NHANES 2011-2016.BMC endocrine disorders · 2025Article
- Facial Appearance and Markers of Cardiometabolic Risk in Healthy Adult Men.Archives of sexual behavior · 2025Article
- Atherogenic Risk in Shift Versus Non-Shift Workers: Associations with Sociodemographic and Lifestyle Factors.Diseases (Basel, Switzerland) · 2025Article
- A Longitudinal Cohort Assessing the Carotid Intima-Media Thickness Progression and Cardiovascular Risk Factors in a Rural Black South African Community.Journal of clinical medicine · 2025Article
- A cross-sectional study of testosterone deficiency and inflammatory markers in older men.Frontiers in endocrinology · 2025Article
- Association between the atherogenic index of plasma and testosterone deficiency in American adults: a cross-sectional study from NHANES 2011-2016.Frontiers in endocrinology · 2025Article
- Is castration leading to biological aging in dogs? Assessment of lipid peroxidation, inflammation, telomere length, mitochondrial DNA copy number, and expression of telomerase and age-related genes.BMC veterinary research · 2024Article
- Inflammation as a Potential Mechanism Contributing to Sexual Functioning Following Initiation of Gender-Affirming Hormone Therapy.Current sexual health reports · 2024Article
- Association between cardiometabolic index and testosterone levels in adult men: NHANES 2011-2016.PloS one · 2024Article
- Immune dynamics throughout life in relation to sex hormones and perspectives gained from gender-affirming hormone therapy.Frontiers in immunology · 2024Review
- Analysis of the association between testosterone and cardiovascular disease potential risk factor apolipoprotein B in adult males without cancer: national health and nutrition examination survey 2011-2016.Frontiers in endocrinology · 2024Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The negative relationship between testosterone and inflammatory cytokines has been reported for decades, although the exact mechanisms of their interactions are still not clear. At the same time, little is known about the relation between androgens and acute phase proteins. Therefore, in this investigation, we aimed to study the relationship between androgen status and inflammatory acute phase reactants in a group of men using multi-linear regression analysis. Venous blood samples were taken from 149 men ranging in age from 18 to 77 years. Gonadal androgens [testosterone (T) and free testosterone (fT)], acute phase reactants [C-reactive protein (CRP), ferritin (FER), alpha-1-acid glycoprotein (AAG), and interleukin-6 (IL-6)], cortisol (C), and lipid profile concentrations were determined. It was demonstrated that the markers of T and fT were negatively correlated with all acute phase proteins (CRP, FER, and AAG;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.