Evidence map›Paper›PMID 34566869›Full record

ArticleFrontiers in neurology2021

Increased Autoimmunity in Individuals With Down Syndrome and Moyamoya Disease.

Jonathan D Santoro, Sarah Lee, Anthony C Wang, Eugenia Ho, Deepti Nagesh, Mellad Khoshnood, Runi Tanna, Ramon A Durazo-Arvizu, Melanie A Manning, Brian G Skotko and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Alternative Diagnoses in the Work Up of Down Syndrome Regression Disorder.Journal of autism and developmental disorders · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Down Syndrome and Autoimmune Disease.Clinical reviews in allergy & immunology · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Review
  15. Case Report:Frontiers in pediatrics · 2023
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Jonathan D SantoroDivision of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Sarah LeeDepartment of Neurology, Stanford University School of Medicine, Palo Alto, CA, United States.
Anthony C WangDepartment of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, United States.
Eugenia HoDivision of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Deepti NageshDivision of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Mellad KhoshnoodDivision of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Runi TannaDivision of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Ramon A Durazo-ArvizuBiostatistics Core, Department of Pediatrics, Keck School of Medicine at the University of Southern California, Los Angeles, CA, United States.
Melanie A ManningDepartment of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, United States.
Brian G SkotkoDepartment of Pediatrics, Harvard Medical School, Boston, MA, United States.
Gary K SteinbergDepartment of Neurosurgery, Stanford University School of Medicine, Palo Alto, CA, United States.
Michael S RafiiDepartment of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, CA, United States.
University of Southern California · USChildren's Hospital of Los Angeles · USStanford University · USMassachusetts General Hospital · USUniversity of California, Los Angeles · US

Funding

Non-invasive biometric screening for cerebrovascular disorders in persons with Down syndrome.K23HL155898 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI SANTORO, JONATHAN DOUGLAS · 2021 to 2025
$1.3M
NHLBI NIH HHS K23 HL155898
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

autoimmune diseasedown syndromemoyamoya diseasepediatricsstroke

Identifiers

PMID34566869
PMCPMC8455812
OpenAlexW3197831149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.