Evidence map›Paper›PMID 34566866›Full record

ArticleFrontiers in neurology2021

MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis.

Laura Clarke, Simon Arnett, Wajih Bukhari, Elham Khalilidehkordi, Sofia Jimenez Sanchez, Cullen O'Gorman, Jing Sun, Kerri M Prain, Mark Woodhall, Roger Silvestrini and 54 more

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In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Blood-Brain Barrier Disruption in Neuroimmunological Disease.International journal of molecular sciences · 2024
    Review
  9. Article
  10. Aquaporins: Gatekeepers of Fluid Dynamics in Traumatic Brain Injury.International journal of molecular sciences · 2024
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

64 authors.

Laura ClarkeMenzies Health Institute Queensland, Gold Coast, Griffith University, Southport, QLD, Australia.
Simon ArnettMenzies Health Institute Queensland, Gold Coast, Griffith University, Southport, QLD, Australia.
Wajih BukhariMenzies Health Institute Queensland, Gold Coast, Griffith University, Southport, QLD, Australia.
Elham KhalilidehkordiMenzies Health Institute Queensland, Gold Coast, Griffith University, Southport, QLD, Australia.
Sofia Jimenez SanchezMenzies Health Institute Queensland, Gold Coast, Griffith University, Southport, QLD, Australia.
Cullen O'GormanMenzies Health Institute Queensland, Gold Coast, Griffith University, Southport, QLD, Australia.
Jing SunMenzies Health Institute Queensland, Gold Coast, Griffith University, Southport, QLD, Australia.
Kerri M PrainDepartment of Immunology, Pathology Queensland, Royal Brisbane and Women's Hospital, Herston, QLD, Australia.
Mark WoodhallNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Roger SilvestriniDepartment of Immunopathology, Westmead Hospital, Westmead, NSW, Australia.
Christine S BundellSchool of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA, Australia.
David A AbernethyDepartment of Neurology, Wellington Hospital, Newtown, New Zealand.
Sandeep BhutaMenzies Health Institute Queensland, Gold Coast, Griffith University, Southport, QLD, Australia.
Stefan BlumDepartment of Neurology, Princess Alexandra Hospital, Woolloongabba, QLD, Australia.
Mike BoggildDepartment of Neurology, Townsville Hospital, Douglas, QLD, Australia.
Karyn BoundyDepartment of Neurology, College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
Bruce J BrewCentre for Applied Medical Research, St. Vincent's Hospital, University of New South Wales, Darlinghurst, NSW, Australia.
Wallace BrownleeDepartment of Neurology, Auckland City Hospital, Grafton, New Zealand.
Helmut ButzkuevenMelbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
William M CarrollCentre for Neuromuscular and Neurological Disorders, Queen Elizabeth II Medical Centre, Perron Institute for Neurological and Translational Science, University of Western Australia, Nedlands, WA, Australia.
Cella ChenDepartment of Ophthalmology, Flinders Medical Centre, Flinders University, Bedford Park, SA, Australia.
Alan CoulthardSchool of Medicine, Royal Brisbane and Women's Hospital, University of Queensland, Herston, QLD, Australia.
Russell C DaleBrain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.
Chandi DasDepartment of Neurology, Canberra Hospital, Garran, ACT, Australia.
Marzena J Fabis-PedriniCentre for Neuromuscular and Neurological Disorders, Queen Elizabeth II Medical Centre, Perron Institute for Neurological and Translational Science, University of Western Australia, Nedlands, WA, Australia.
David GillisSchool of Medicine, Royal Brisbane and Women's Hospital, University of Queensland, Herston, QLD, Australia.
Simon HawkeSydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, NSW, Australia.
Robert HeardBrain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.
Andrew P D HendersonDepartment of Neurology, Westmead Hospital, Westmead, NSW, Australia.
Saman HeshmatMenzies Health Institute Queensland, Gold Coast, Griffith University, Southport, QLD, Australia.
Suzanne HodgkinsonSouth Western Sydney Medical School, Liverpool Hospital, University of New South Wales, Liverpool, NSW, Australia.
Trevor J KilpatrickFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
John KingDepartment of Neurology, Royal Melbourne Hospital, Parkville, VIC, Australia.
Christopher KneeboneDepartment of Neurology, Royal Adelaide Hospital, Adelaide, SA, Australia.
Andrew J KornbergSchool of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, VIC, Australia.
Jeannette Lechner-ScottHunter Medical Research Institute, University of Newcastle, New Lambton Heights, NSW, Australia.
Ming-Wei LinSydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, NSW, Australia.
Christopher LynchSchool of Medicine, University of Auckland, Grafton, New Zealand.
Richard A L MacdonellDepartment of Neurology, Austin Health, Heidelberg, VIC, Australia.
Deborah F MasonDepartment of Neurology, Christchurch Hospital, Christchurch, New Zealand.
Pamela A McCombeCentre for Clinical Research, Royal Brisbane and Women's Hospital, University of Queensland, Herston, QLD, Australia.
Jennifer PereiraSchool of Medicine, University of Auckland, Grafton, New Zealand.
John D PollardSydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, NSW, Australia.
Sudarshini RamanathanNeuroimmunology Group, Kids Neurosciences Centre, Children's Hospital at Westmead, University of Sydney, Westmead, NSW, Australia.
Stephen W ReddelBrain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.
Cameron P ShawSchool of Medicine, Deakin University, Waurn Ponds, VIC, Australia.
Judith M SpiesSydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, NSW, Australia.
James StankovichMenzies Research Institute, University of Tasmania, Hobart, TAS, Australia.
Ian SuttonDepartment of Neurology, St. Vincent's Hospital, Darlinghurst, NSW, Australia.
Steve VucicDepartment of Neurology, Westmead Hospital, Westmead, NSW, Australia.
Michael WalshDepartment of Neurology, Princess Alexandra Hospital, Woolloongabba, QLD, Australia.
Richard C WongSchool of Medicine, Royal Brisbane and Women's Hospital, University of Queensland, Herston, QLD, Australia.
Eppie M YiuSchool of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, VIC, Australia.
Michael H BarnettBrain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.
Allan G K KermodeCentre for Neuromuscular and Neurological Disorders, Queen Elizabeth II Medical Centre, Perron Institute for Neurological and Translational Science, University of Western Australia, Nedlands, WA, Australia.
Mark P MarriottMelbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
John D E ParrattSydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, NSW, Australia.
Mark SleeDepartment of Neurology, College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
Bruce V TaylorMenzies Research Institute, University of Tasmania, Hobart, TAS, Australia.
Ernest WilloughbyDepartment of Neurology, Auckland City Hospital, Grafton, New Zealand.
Fabienne BrilotBrain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.
Angela VincentNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Patrick WatersNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Simon A BroadleyMenzies Health Institute Queensland, Gold Coast, Griffith University, Southport, QLD, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the CNS. Overlap in the clinical and MRI features of NMOSD and MS means that distinguishing these conditions can be difficult. With the aim of evaluating the diagnostic utility of MRI features in distinguishing NMOSD from MS, we have conducted a cross-sectional analysis of imaging data and developed predictive models to distinguish the two conditions. NMOSD and MS MRI lesions were identified and defined through a literature search. Aquaporin-4 (AQP4) antibody positive NMOSD cases and age- and sex-matched MS cases were collected. MRI of orbits, brain and spine were reported by at least two blinded reviewers. MRI brain or spine was available for 166/168 (99%) of cases. Longitudinally extensive (OR = 203), "bright spotty" (OR = 93.8), whole (axial; OR = 57.8) or gadolinium (Gd) enhancing (OR = 28.6) spinal cord lesions, bilateral (OR = 31.3) or Gd-enhancing (OR = 15.4) optic nerve lesions, and nucleus tractus solitarius (OR = 19.2), periaqueductal (OR = 16.8) or hypothalamic (OR = 7.2) brain lesions were associated with NMOSD. Ovoid (OR = 0.029), Dawson's fingers (OR = 0.031), pyramidal corpus callosum (OR = 0.058), periventricular (OR = 0.136), temporal lobe (OR = 0.137) and T1 black holes (OR = 0.154) brain lesions were associated with MS. A score-based algorithm and a decision tree determined by machine learning accurately predicted more than 85% of both diagnoses using first available imaging alone. We have confirmed NMOSD and MS specific MRI features and combined these in predictive models that can accurately identify more than 85% of cases as either AQP4 seropositive NMOSD or MS.

Indexed as

diagnosismagnetic resonance imagingmultiple sclerosisneuromyelitis opticaNMOSD

Identifiers

PMID34566866
PMCPMC8458658

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.