Evidence map›Paper›PMID 34566858›Full record

ArticleFrontiers in neurology2021

Increased Sodium Concentration in Substantia Nigra in Early Parkinson's Disease: A Preliminary Study With Ultra-High Field (7T) MRI.

Stephan Grimaldi, Mohamed Mounir El Mendili, Wafaa Zaaraoui, Jean-Philippe Ranjeva, Jean-Philippe Azulay, Alexandre Eusebio, Maxime Guye

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Stephan GrimaldiAPHM, Hôpital Universitaire Timone, Department of Neurology and Movement Disorders, Marseille, France.
Mohamed Mounir El MendiliAPHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France.
Wafaa ZaaraouiAPHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France.
Jean-Philippe RanjevaAPHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France.
Jean-Philippe AzulayAPHM, Hôpital Universitaire Timone, Department of Neurology and Movement Disorders, Marseille, France.
Alexandre EusebioAPHM, Hôpital Universitaire Timone, Department of Neurology and Movement Disorders, Marseille, France.
Maxime GuyeAPHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France.
Hôpital de la Timone · FRAix-Marseille Université · FRCentre de Résonance Magnétique Biologique et Médicale · FRCentre National de la Recherche Scientifique · FRInstitut de Neurosciences de la Timone · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathophysiology of idiopathic Parkinson's disease (iPD) is complex and still misunderstood. At a time when treatments with disease-modifying potential are being developed, identification of early markers of neurodegeneration is essential. Intracerebral sodium accumulation could be one of them. Indeed, it may be in relation to the mitochondrial dysfunction that early exists in iPD. For the first time, we used brain sodium (

Indexed as

biomarkerneurodegenerationParkinson's diseasesodiumultra high field magnetic resonance imaging

Identifiers

PMID34566858
PMCPMC8458803
OpenAlexW3199951059

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.