ReviewFrontiers in neurology2021
Evidence-Based Updates to Thrombectomy: Targets, New Techniques, and Devices.
Review in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy and safety of intravenous tirofiban pre-operatively as an adjunct to endovascular thrombectomy in ischemic stroke: a grade-assessed systematic review and Meta-Analysis.Journal of thrombosis and thrombolysis · 2026Pooled it
- Thrombectomy for distal medium vessel occlusion stroke: Combined vs. single-device techniques - A systematic review and meta-analysis.Frontiers in stroke · 2023Pooled it
- Blood pressure management in patients receiving rescue stenting after failed endovascular treatment in large vessel occlusion acute ischaemic stroke: a multicentre registry.European stroke journal · 2026Article
- Comparison of mechanical thrombectomy alone versus post-IV t-PA thrombectomy in acute large artery occlusion within 4.5 hours of symptom onset.Journal of cerebrovascular and endovascular neurosurgery · 2025Article
- Potential of Guidewire-Clot Interaction Forces for Clot Detection in Robotic Mechanical Thrombectomy.The international journal of medical robotics + computer assisted surgery : MRCAS · 2025Article
- Rescue therapy after failed thrombectomy in medium/distal vessel occlusions: A retrospective analysis of an international, multi-center registry.European stroke journal · 2025Article
- Deep learning to identify stroke within 4.5 h using DWI and FLAIR in a prospective multicenter study.Scientific reports · 2025Article
- Contemporary Trends in Utilization of Rescue Intracranial Stenting During Mechanical Thrombectomy in Patients With Stroke in the United States.Stroke (Hoboken, N.J.) · 2025Article
- Endovascular Thrombectomy at a Government Tertiary Hospital in the Philippines: A Case Series.Acta medica Philippina · 2025Article
- Blood-brain barrier repair: potential and challenges of stem cells and exosomes in stroke treatment.Frontiers in cellular neuroscience · 2025Review
- Medicine Meets Science: The Imperative of Scientific Research and Publishing for Physician-Scientists.The Indian journal of radiology & imaging · 2025Article
- Review
- Predicting Recanalization Failure With Conventional Devices During Endovascular Treatment Related to Vessel Occlusion.Stroke (Hoboken, N.J.) · 2024Article
- Cost-Effectiveness of Prehospital Ambulance Helicopter Transportation of Patients With Presumed Stroke in the Era of Mechanical Thrombectomy.Stroke (Hoboken, N.J.) · 2024Article
- Outcomes and Complications Associated with Mechanical Thrombectomy in the Treatment of Acute Ischemic Stroke.Cardiology and cardiovascular medicine · 2024Article
- Article
- Pupillometry in the follow-up of patients undergoing EVT - prediction of space-occupying hemispheric infarction.Journal of neurology · 2023Article
- Mechanical thrombectomy with combined stent retriever and contact aspiration versus stent retriever alone for acute large vessel occlusion: data from ANGEL-ACT registry.Stroke and vascular neurology · 2023Article
- The effect of intravenous thrombolysis on patients with successful thrombectomy depends on final reperfusion grade: A retrospective study.CNS neuroscience & therapeutics · 2023Article
- Advances in Acute Ischemic Stroke Treatment: Current Status and Future Directions.AJNR. American journal of neuroradiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endovascular thrombectomy (EVT) has been validated in several randomized controlled trials in recent years for its efficacy in the treatment of acute ischemic strokes (AIS) and is now the standard of care according to international guidelines. However, in about 20% of EVT procedures, recanalization is not achieved, and over 50% of patients who undergo EVT still do not have good functional outcome. In this article, we provide an extensive review of the latest evidence and developments in the field of EVT, with particular focus on the factors that improve patient outcomes. These factors include new and adjunctive techniques such as combination of direct aspiration and stent retriever, intra-arterial urokinase or 2b/3a inhibitors, rescue stenting, as well as novel devices including balloon guide catheters and the newer generations of aspiration catheters and stent retrievers. We also examined the latest notion of using first-pass effect (FPE) as the target to achieve during EVT, which has been associated with an improved functional outcome. While the field of EVT has been rapidly evolving, further research is required in specific AIS patient populations such as those with large ischemic core, late presentation beyond 24 h, posterior circulation strokes, and with distal medium vessel occlusion or tandem lesions to better assess its efficacy and safety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.