Evidence map›Paper›PMID 34566844›Full record

ArticleFrontiers in neurology2021

Excessive White Matter Hyperintensity Increases Susceptibility to Poor Functional Outcomes After Acute Ischemic Stroke.

Sungmin Hong, Anne-Katrin Giese, Markus D Schirmer, Anna K Bonkhoff, Martin Bretzner, Pamela Rist, Adrian V Dalca, Robert W Regenhardt, Mark R Etherton, Kathleen L Donahue and 47 more

Abstract read
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. White Matter Hyperintensities as a Predictor of Aphasia Recovery.Archives of physical medicine and rehabilitation · 2024
    Trial
  2. Review
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  6. Comparison of ischemic and hemorrhagic stroke in the thalamus.Quantitative imaging in medicine and surgery · 2026
    Article
  7. Article
  8. Article
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  15. Neuroimaging markers of patient-reported outcome measures in acute ischemic stroke.medRxiv : the preprint server for health sciences · 2023
    Article
  16. Review
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

57 authors.

Sungmin HongJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Anne-Katrin GieseDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Markus D SchirmerJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Anna K BonkhoffJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Martin BretznerJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Pamela RistDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Adrian V DalcaComputer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Boston, MA, United States.
Robert W RegenhardtJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Mark R EthertonJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Kathleen L DonahueJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Marco NardinJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Steven J T MockingAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States.
Elissa C McIntoshAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States.
John AttiaHunter Medical Research Institute, Newcastle, NSW, Australia.
Oscar R BenaventeDivision of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
John W ColeDepartment of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore, MD, United States.
Amanda DonattiSchool of Medical Sciences, University of Campinas (UNICAMP) and the Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), Campinas, Brazil.
Christoph J GriessenauerDepartment of Neurosurgery, Geisinger, Danville, PA, United States.
Laura HeitschDivision of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Lukas HolmegaardDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg and Department of Neurology, The Sahlgrenska University Hospital, Gothenburg, Sweden.
Katarina JoodDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg and Department of Neurology, The Sahlgrenska University Hospital, Gothenburg, Sweden.
Jordi Jimenez-CondeDepartment of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions M'ediques), Universitat Autonoma de Barcelona, Barcelona, Spain.
Jaume RoquerDepartment of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions M'ediques), Universitat Autonoma de Barcelona, Barcelona, Spain.
Steven J KittnerDepartment of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore, MD, United States.
Robin LemmensKU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium.
Christopher R LeviHunter Medical Research Institute, Newcastle, NSW, Australia.
Caitrin W McDonoughDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL, United States.
James F MeschiaDepartment of Neurology, Mayo Clinic, Jacksonville, FL, United States.
Chia-Ling PhuahDepartment of Neurology, Washington University School of Medicine & Barnes-Jewish Hospital, St. Louis, MO, United States.
Arndt RolfsCentogene AG, Rostock, Germany.
Stefan RopeleDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria.
Jonathan RosandJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Tatjana RundekDepartment of Neurology and Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL, United States.
Ralph L SaccoDepartment of Neurology and Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL, United States.
Reinhold SchmidtDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria.
Christian EnzingerDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria.
Pankaj SharmaInstitute of Cardiovascular Research, Royal Holloway University of London (ICR2UL), Egham, United Kingdom.
Agnieszka SlowikDepartment of Neurology, Jagiellonian University Medical College, Krakow, Poland.
Alessandro SousaSchool of Medical Sciences, University of Campinas (UNICAMP) and the Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), Campinas, Brazil.
Tara M StanneDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg and Department of Neurology, The Sahlgrenska University Hospital, Gothenburg, Sweden.
Daniel StrbianDepartment of Neurology, Helsinki University Hospital and Clinical Neurosciences, University of Helsinki, Helsinki, Finland.
Turgut TatlisumakDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Vincent ThijsStroke Division, Florey Institute of Neuroscience and Mental Health, Heidelberg, VIC, Australia.
Achala VagalDepartment of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Johan WasseliusDepartment of Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden.
Daniel WooDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Ramin ZandDepartment of Neurology, Geisinger, Danville, PA, United States.
Patrick F McArdleDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.
Bradford B WorrallDepartments of Neurology and Public Health Sciences, University of Virginia, Charlottesville, VA, United States.
Ona WuAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States.
Christina JernDepartment of Laboratory Medicine, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Arne G LindgrenDepartment of Neurology and Rehabilitation Medicine, Skåne University Hospital, Lund, Sweden.
Jane MaguireSchool of Nursing and Midwifery, University of Technology Sydney, Sydney, NSW, Australia.
Liisa TomppoDepartment of Neurology, Helsinki University Hospital and Clinical Neurosciences, University of Helsinki, Helsinki, Finland.
Polina GollandComputer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Boston, MA, United States.
Natalia S RostJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium

Funding

Genetics of Early-Onset Ischemic Stroke ConsortiumR01NS105150 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J, MITCHELL, BRAXTON D · 2018 to 2022
$3.0M
CNV And Stroke (CaNVAS)R01NS114045 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI COLE, JOHN W. · 2020 to 2024
$2.6M
BLRD VA I01 BX004672NINDS NIH HHS R01 NS114045
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

acute ischemic strokebrain healthbrain vulnerabilityfunctional independencefunctional outcome after acute strokepost-stroke outcomesstrokewhite matter hyper intensity

Identifiers

PMID34566844
PMCPMC8461233

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.