ArticleFrontiers in physiology2021
Association of Short-Term Heart Rate Variability With Breast Tumor Stage.
Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Key role of the autonomic nervous system in breast cancer (Review).Experimental and therapeutic medicine · 2026Review
- ECG-derived Poincaré plot graphical metrics for differentiating axillary lymph node metastasis in breast cancer.Frontiers in physiology · 2026Article
- Predictors and Clinical Impacts of Impaired Heart Rate Variability in Women with Breast Cancer.Medicina (Kaunas, Lithuania) · 2025Article
- Pulse rate variability is not the same as heart rate variability: findings from a large, diverse clinical population study.Frontiers in physiology · 2025Article
- Association of Sympathovagal Imbalance with Increased Inflammation and Impaired Adaptive Immunity in Bladder Cancer Patients.International journal of molecular sciences · 2024Article
- Increased stress burden and electrodermal reactivity in bladder cancer patients in comparison to healthy controls.Heliyon · 2024Article
- Tracking Cancer: Exploring Heart Rate Variability Patterns by Cancer Location and Progression.Cancers · 2024Article
- The relationship between heart rate variability and TNM stage, co-morbidity, systemic inflammation and survival in patients with primary operable colorectal cancer.Scientific reports · 2023Article
- Prognostic role of short-term heart rate variability and deceleration/acceleration capacities of heart rate in extensive-stage small cell lung cancer.Frontiers in physiology · 2023Article
- Exploring autonomic modulation: day-to-day recovery after exercise sessions in breast cancer survivors.Frontiers in oncology · 2023Article
- Association of heartbeat complexity with survival in advanced non-small cell lung cancer patients.Frontiers in neuroscience · 2023Article
- Diagnostic role of heart rate variability in breast cancer and its relationship with peripheral serum carcinoembryonic antigen.PloS one · 2023Article
- Increased sympathetic modulation in breast cancer survivors determined by measurement of heart rate variability.Scientific reports · 2022Article
- The Mechanism of Cardiac Sympathetic Activity Assessment Methods: Current Knowledge.Frontiers in cardiovascular medicine · 2022Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac autonomic modulation, assessed by heart rate variability (HRV), is associated with tumor pathogenesis and development as well as invasion and metastasis. This study aimed to examine this association in breast cancer (BC) patients. A total of 133 patients (average age 49.2years) with BC or benign breast tumors were divided into three groups: benign group, early-stage group, and advanced-stage group. About 5-min resting ECG was collected for the analysis of linear and nonlinear HRV parameters. Multiple logistic regression models were performed to test the independent contribution of HRV to breast tumor stage. The advanced-stage group had significantly reduced HRV compared to the benign and early-stage groups. In particular, for each 1-SD increase in SD2, SD of normal-to-normal intervals, very-low frequency, total power, and low frequency, the odds of having advanced staging decreased by 69.3, 64.3, 58.3, 53.3, and 65.9%, respectively. These associations were independent of age, body mass index, mean heart rate (HR), and respiratory rate (RR). These findings suggest an association between HRV and breast tumor stage, and HRV parameters may help construct an effective early diagnostic and clinical prognostic model.
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