Evidence map›Paper›PMID 34566645›Full record

ArticleFrontiers in pharmacology2021

Metabolomics Analysis Reveals Interaction of Base-Line Chemotherapy and Shiyiwei Shenqi Tablets in Breast Cancer Treatment.

Hong Wan, Xiaojun Xu, Xiaowei Yang, Angqing Li, Xiaopeng Ma, Aman Xu, Xiao Yuan, Wenbin Wang, Tao Guo, Guangtao Luo and 7 more

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In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Hong WanDepartment of General Surgery, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China.
Xiaojun XuDepartment of Breast Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Xiaowei YangDepartment of Breast Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Angqing LiDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Xiaopeng MaDepartment of Thyroid and Breast Surgery, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China.
Aman XuDepartment of General Surgery, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China.
Xiao YuanDepartment of General Surgery, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China.
Wenbin WangDepartment of General Surgery, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China.
Tao GuoDepartment of General Surgery, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China.
Guangtao LuoDepartment of Breast Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Xiaobo HeDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Wang LiDepartment of Head and Neck Surgery, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China.
Zhaorui WangDepartment of Breast Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Qiang SunCancer Institute, Xuzhou Medical University, Xuzhou, China.
Jing PeiDepartment of Breast Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yongzhen GuoDepartment of Pathology, The Third Affliated Hospital of Zhengzhou University, Zhengzhou, China.
Yong ZhuDepartment of General Surgery, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shiyiwei Shenqi Tablet (SSTs) has been widely used for treatment of different types of cancer including breast cancer. SST has drawn more and more interest due to the low rate of side effects. The aim of this study was to investigate the metabolites in serums of breast cancer patients who received base-line chemotherapy only or combination treatment with SST. An untargeted metabolomics method was developed to investigate the alteration of metabolism in patients' serums using ultra-high-performance liquid chromatography/Q-exactive Orbitrap mass spectrometry. The patients were separated based on the metabolomics data, and further analyses showed that SST treatment can affect the metabolism of glucose, fatty acid, bile acid and amino acid. In particular, SST treatment significantly reduced some short peptides which are potential tumor neoantigens. This study may provide novel insights into the mechanism underlying interaction between SST and base-line chemotherapy in terms of affecting metabolic pathways and thereby changing metabolic products, which might shed new light for clinical medication.

Indexed as

amino acid metabolismbreast cancershiyiwei shenqi tabletsside effectsuntargeted metabolomics

Identifiers

PMID34566645
PMCPMC8461015

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.