Evidence map›Paper›PMID 34566593›Full record

ArticleFrontiers in behavioral neuroscience2021

Prenatal Maternal Stress From a Natural Disaster and Hippocampal Volumes: Gene-by-Environment Interactions in Young Adolescents From Project Ice Storm.

Lei Cao-Lei, Sandra Yogendran, Romane Dufoix, Guillaume Elgbeili, David P Laplante, Suzanne King

Open access · goldAbstract read
In one paragraph

Article in Frontiers in behavioral neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Sex and Gender Influences on the Impacts of Disasters: A Rapid Review of Evidence.International journal of environmental research and public health · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Superstorm Sandy exposureFrontiers in neuroscience · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Lei Cao-LeiDepartment of Psychiatry, McGill University, Montreal, QC, Canada.
Sandra YogendranDepartment of Psychiatry, McGill University, Montreal, QC, Canada.
Romane DufoixDepartment of Psychiatry, McGill University, Montreal, QC, Canada.
Guillaume ElgbeiliDouglas Hospital Research Centre, Montreal, QC, Canada.
David P LaplanteCentre for Child Development and Mental Health, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada.
Suzanne KingDepartment of Psychiatry, McGill University, Montreal, QC, Canada.
Douglas College · CAMcGill University · CADouglas Mental Health University Institute · CAJewish General Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene-by-environment interactions influence brain development from conception to adulthood. In particular, the prenatal period is a window of vulnerability for the interplay between environmental and genetic factors to influence brain development. Rodent and human research demonstrates that prenatal maternal stress (PNMS) alters hippocampal volumes. Although PNMS affects hippocampal size on average, similar degrees of PNMS lead to different effects in different individuals. This differential susceptibility to the effects of PNMS may be due to genetic variants. Hence, we investigated the role of genetic variants of two SNPs that are candidates to moderate the effects of PNMS on hippocampal volume: COMT (rs4680) and BDNF (rs6265). To investigate this, we assessed 53 children who were

Indexed as

BDNFCOMTgene-by-environment interactionshippocampal volumesnatural disasterprenatal maternal stress (PNMS)

Identifiers

PMID34566593
PMCPMC8461021
OpenAlexW3200766497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.