Evidence map›Paper›PMID 34566248›Full record

ArticleHeterocycles2021

SYNTHESIS OF PROBE MOLECULES, 6-(DIMETHYLAMINO)-2-PHENYLISOINDOLIN-1-ONES, FOR MECHANISTIC STUDIES OF FIREFLY LUCIFERASE INHIBITION.

Medha J Gunaratna, Bo Hao, Man Zhang, Madoka Nakagomi, Ai Ito, Takeo Iwamoto, Duy H Hua

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heterocycles, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Medha J GunaratnaDepartment of Chemistry, 1212 Mid Campus Drive N., Kansas State University, Manhattan, KS 66506, U.S.A.
Bo HaoDepartment of Chemistry, 1212 Mid Campus Drive N., Kansas State University, Manhattan, KS 66506, U.S.A.
Man ZhangDepartment of Chemistry, 1212 Mid Campus Drive N., Kansas State University, Manhattan, KS 66506, U.S.A.
Madoka NakagomiResearch Foundation ITSUU Laboratory, C1232 Kanagawa Science Park R&D Building, 3-2-1 Sakado, Takatsu-ku, Kawasaki, Kanagawa, 213-0012, Japan.
Ai ItoShowa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo, 194-8543, Japan.
Takeo IwamotoCore Research Facilities, The Jikei University School of Medicine, Tokyo, 105-8461, Japan.
Duy H HuaDepartment of Chemistry, 1212 Mid Campus Drive N., Kansas State University, Manhattan, KS 66506, U.S.A.

Funding

Catalytic Asymmetric Oxidation of Alkenes and AlkanesR01GM128659 · NIGMS · KANSAS STATE UNIVERSITY · PI HUA, DUY H · 2019 to 2022
$1.3M
NIGMS NIH HHS R01 GM128659
6 · The paper itself

Abstract

Firefly luciferase is used in high-throughput screening based on the detection of chemiluminescence. It catalyzes an esterification reaction of luciferin with adenosine 5'-triphosphate (ATP) followed by decarbonylation with oxygen and concomitance of light. Previously, we reported that firefly luciferase also possesses acyl-CoA synthetase activity and catalyzes an aromatic carboxylic acid group of F-53, using ATP, Mg

Identifiers

PMID34566248
PMCPMC8460084

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.