Evidence map›Paper›PMID 34565785›Full record

ArticleThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi2021

Early Cardiac Dysfunction in Biopsy-proven Nonalcoholic Fatty Liver Disease.

Peter C Johnson, Anthony A Cochet, Rosco S Gore, Stephen A Harrison, John P Magulick, James K Aden, Angelo H Paredes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Peter C JohnsonDepartment of Medicine, Brooke Army Medical Center, San Antonio, TX, USA.ORCID https://orcid.org/0000-0003-4466-3052
Anthony A CochetDepartment of Medicine, Cardiology Service, Brooke Army Medical Center, San Antonio, TX, USA.
Rosco S GoreDepartment of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD, USA.
Stephen A HarrisonPinnacle Clinical Research, San Antonio, TX, USA.
John P MagulickDepartment of Medicine, Gastroenterology and Hepatology Service, Brooke Army Medical Center, San Antonio, TX, USA.
James K AdenUS Army Institute for Surgical Research, San Antonio, TX, USA.
Angelo H ParedesDepartment of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD, USA.
Brooke Army Medical Center · USMalcolm Grow Medical Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUNDS/

aimsNonalcoholic fatty liver disease (NAFLD) encompasses a range of diseases from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) and has been linked to cardiovascular disease and sub-clinical cardiac remodeling. This paper presents a retrospective study of biopsy-proven NAFL and NASH to examine the differences in subclinical cardiac remodeling.

methodsPatients were recruited from an institutional repository of patients with liver-biopsy-confirmed NAFLD. Patients with a transthoracic echocardiogram (TTE) within 12 months of the liver biopsy were included. The parameters of the diastolic dysfunction were reviewed for the differences between NAFL and NASH as well as between the stages and grades of NASH.

resultsThirty-three patients were included in the study, 17 with NAFL and 16 with NASH. The NASH patients were more likely to have lower platelets, higher AST, higher ALT, and higher rates of type 2 diabetes mellitus, coronary artery disease, and hypertension than the NAFL patients. The E/e' ratio on transthoracic echocardiogram was significantly higher in NASH compared to NAFL, advanced-stage NASH compared to early stage, and high-grade NASH compared to low-grade. The E/e' ratio was also significantly higher in NASH than NAFL in patients without diabetes mellitus. The presence of diastolic dysfunction trended toward significance. The other markers of diastolic dysfunction were similar. Logistic regression revealed a statistical association with E/e' and NASH.

conclusionsNASH patients had evidence of a higher E/e' ratio than NAFL, and there was a trend towards a significant diastolic dysfunction. Patients with NASH compared to NAFL should be closely monitored for signs and symptoms of cardiac dysfunction.

Indexed as

Diabetes Mellitus, Type 2Heart DiseasesNon-alcoholic Fatty Liver DiseaseBiopsyHumansLiverRetrospective StudiesCardiac diseasesDiastolic heart failureNon-alcoholic fatty liver diseaseSteatohepatitis

Identifiers

PMID34565785
PMCPMC12286248
OpenAlexW3203061987

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.